| Interleukin 23 in acute inflammatory demyelination of the peripheral nerve. | |
| | |
MedLine Citation:
|
PMID: 16769867 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: Interleukin (IL) 23, a newly identified heterodimeric proinflammatory cytokine and a novel IL-12 family member comprising the p40 subunit of IL-12 but a different p19 subunit, has been reported to preferentially act on memory T cells and play an important role during cellular immune responses. Recent evidence suggests that IL-23 rather than IL-12 is critically involved in the pathogenesis of various immune-mediated disorders. OBJECTIVE: To determine the role of IL-23p19 during the course of acute immune-mediated demyelinating diseases of the peripheral nervous system. DESIGN: The sequential RNA expression of IL-23p19 in sciatic nerves from rats with experimental autoimmune neuritis, an animal model of the human Guillain-Barré syndrome (GBS), was analyzed by semiquantitative reverse transcriptase-polymerase chain reaction. Expression and distribution patterns of IL-23p19 protein were studied in sural nerve biopsies and cerebrospinal fluid samples from 5 patients with classical Guillain-Barré syndrome and 5 controls with noninflammatory neuropathies using immunohistochemistry and immunoblotting, respectively. RESULTS: We found IL-23p19 RNA to be up-regulated prior to the onset of first clinical symptoms with peak expression levels preceding maximum disease severity during experimental autoimmune neuritis. In patients, IL-23p19 protein was detectable in cerebrospinal fluid samples from patients with Guillain-Barré syndrome, and endoneurial macrophages were identified as the cellular source of IL-23p19 in sural nerve biopsies. CONCLUSION: Our present data indicate that IL-23 may play an important role during the early effector phase in immune-mediated demyelination of the peripheral nerve. |
| | |
Authors:
|
Wei Hu; Thomas Dehmel; Jaana Pirhonen; Hans-Peter Hartung; Bernd C Kieseier |
Related Documents
:
|
11369647 - Activation of the formyl peptide receptor by the hiv-derived peptide t-20 suppresses in... 19438607 - A suppressive oligodeoxynucleotide inhibits ocular inflammation. 10579467 - Melatonin activates th1 lymphocytes by increasing il-12 production. 8645987 - Production and modulation of t-cell cytokines in atopic allergy. 12093007 - Suppressors of cytokine signalling (socs) in the immune system. 23442647 - A porphyra columbina hydrolysate upregulates il-10 production in rat macrophages and ly... |
Publication Detail:
|
Type: Comparative Study; Journal Article |
Journal Detail:
|
Title: Archives of neurology Volume: 63 ISSN: 0003-9942 ISO Abbreviation: Arch. Neurol. Publication Date: 2006 Jun |
Date Detail:
|
Created Date: 2006-06-13 Completed Date: 2006-07-26 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0372436 Medline TA: Arch Neurol Country: United States |
Other Details:
|
Languages: eng Pagination: 858-64 Citation Subset: AIM; IM |
Affiliation:
|
Department of Neurology, Research Group for Clinical and Experimental Neuroimmunology, Heinrich-Heine-University, Düsseldorf, Germany. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Blotting, Western / methods Disease Models, Animal Female Fluorescent Antibody Technique / methods Guillain-Barre Syndrome / metabolism*, pathology Humans Interleukin-23 Interleukin-23 Subunit p19 Interleukins / genetics, metabolism* Male Neuritis, Autoimmune, Experimental / metabolism*, pathology Peripheral Nerves / metabolism*, pathology RNA, Messenger / metabolism Rats Rats, Inbred Lew Reverse Transcriptase Polymerase Chain Reaction / methods Time Factors |
| Chemical | |
Reg. No./Substance:
|
0/IL23A protein, human; 0/Il23a protein, rat; 0/Interleukin-23; 0/Interleukin-23 Subunit p19; 0/Interleukins; 0/RNA, Messenger |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Neuromyelitis optica in patients with myasthenia gravis who underwent thymectomy.
Next Document: Cognitive measures predict pathologic Alzheimer disease.