Document Detail


Interleukin-22 detected in patients with abdominal sepsis.
MedLine Citation:
PMID:  20220564     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Interleukin 22 (IL-22) is a TH17-like cytokine known to specifically activate epithelial cells, thereby strengthening immune defense at host/environment interfaces. Animal studies suggest that IL-22 may play a crucial role in clinical sepsis. However, little is known about IL-22 in sepsis patients. In a single-center university hospital setting, serum IL-22 levels were assessed in 16 patients with the diagnosis of abdominal sepsis, 16 patients who have undergone elective major abdominal surgery without the diagnosis of sepsis, and 21 healthy volunteers. In accordance with current knowledge, we observed enhanced levels of IL-6 and IL-10 in serum specimens of sepsis patients compared with surgical control patients. Here, we report, for the first time, a modest but significant elevation of serum IL-22 detectable in abdominal sepsis patients (P G 0.001). Median serum concentrations of IL-22 were 111.8 pg/mL, 3.4 or 2.0 pg/mL, and 9.3 pg/mL for abdominal sepsis patients, surgical control patients (presurgery or postsurgery), and healthy volunteers,respectively. Interleukin 22 produced in the course of abdominal sepsis may contribute to host defense and stabilization of mucosal barrier functions under conditions of systemic infection.
Authors:
Tobias M Bingold; Elisabeth Ziesché; Bertram Scheller; Christian D Sadik; Katharina Franck; Lara Just; Sven Sartorius; Mathis Wahrmann; Heimo Wissing; Bernhard Zwissler; Josef Pfeilschifter; Heiko Mühl
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Shock (Augusta, Ga.)     Volume:  34     ISSN:  1540-0514     ISO Abbreviation:  Shock     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-09-22     Completed Date:  2010-12-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9421564     Medline TA:  Shock     Country:  United States    
Other Details:
Languages:  eng     Pagination:  337-40     Citation Subset:  IM    
Affiliation:
Department of Anaesthesiology, Intensive Care Medicine and Pain Therapy, Goethe-University Frankfurt School of Medicine, Germany.
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MeSH Terms
Descriptor/Qualifier:
Abdominal Injuries / blood
Adult
Aged
Enzyme-Linked Immunosorbent Assay
Female
Humans
Interleukin-10 / blood
Interleukin-6 / blood
Interleukins / blood*
Male
Middle Aged
Sepsis / blood*,  immunology
Chemical
Reg. No./Substance:
0/Interleukin-6; 0/Interleukins; 0/interleukin-22; 130068-27-8/Interleukin-10

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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