| Interleukin-21 Expression and its Association with Pro-Inflammatory Cytokines in Untreated Chronic Periodontitis Patients. | |
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MedLine Citation:
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PMID: 22181687 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Background: IL-21 controls the differentiation of T(H)17 cells and induces the production of IL-17 in this T cell subtype. The aim of this study was to determine the relative expression of IL-21 in gingival tissues of chronic periodontitis patients and correlate/associate this expression with pro-inflammatory cytokines and clinical parameters of disease. Methods: Samples of gingival biopsies were collected from chronic periodontitis patients (n=10) and control subjects (n=8). The mRNA expressions of IL-21, IL-1β, IL-6, IL-17, IL-23, IL-10 and TGF-β1 were quantified using real-time reverse transcription-polymerase chain reaction. IL-21 levels were compared between chronic periodontitis and healthy gingival tissues and correlated with cytokine and clinical parameters of tissue destruction. Results: A significant over-expression of IL-21, IL-1β, IL-6, IL-17 and IL-23p19 was detected in periodontal disease affected tissues compared with healthy gingival tissues. IL-10 and TGF-β1 were, however, down-regulated in periodontal lesions. IL-21 yielded significant positive correlations with PD; CAL; IL-1β and IL-6. In addition, IL-21 was negatively correlated with IL-10 and TGF-β1. Conclusion: IL-21 is over-expressed in chronic periodontitis gingival tissues and correlated with clinical parameters of periodontal destruction and with pro-inflammatory cytokines. Therefore, IL-21 might play a role in the tissue destruction which characterize chronic periodontal disease. |
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Authors:
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Nicolás Dutzan; Rolando Vernal; Jose P Vaque; Jocelyn García-Sesnich; Marcela Hernandez; Loreto Abusleme; Andrea Dezerega; J Silvio Gutkind; Jorge Gamonal |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-12-19 |
Journal Detail:
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Title: Journal of periodontology Volume: - ISSN: 1943-3670 ISO Abbreviation: - Publication Date: 2011 Dec |
Date Detail:
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Created Date: 2011-12-20 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8000345 Medline TA: J Periodontol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Laboratory of Periodontal Biology, Department of Conservative Dentistry, Faculty of Dentistry, University of Chile, Santiago, Chile. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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