| Interleukin-20 targets renal cells and is associated with chronic kidney disease. | |
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MedLine Citation:
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PMID: 18639518 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Interleukin (IL)-10 is an anti-inflammatory factor that suppresses renal fibrosis and improves renal function in CKD rats. IL-20 belongs to the IL-10 family; therefore, we sought to determine whether IL-20 is involved in CKD. CKD patients at stage five expressed significantly higher IL-20 in serum than controls. Immunohistochemical staining demonstrated that more IL-20 protein was expressed in the kidney tubular-epithelial cells, mesangial cells, and immune cells of CKD rats with a 5/6 nephrectomy. The lung, liver, and heart tissue of CKD rats also overexpressed IL-20. Thus, we treated two tubular epithelial cells, TKPTS and M-1 cells, with IL-20 to study its effects on CKD. IL-20 treatment induced apoptosis in these cells via caspase-3 activation. Incubating IL-20 with rat interstitial fibroblasts, NRK-49F cells, upregulated TGF-beta1 production, one key inducer for renal fibrogenesis. Therefore, IL-20 injured renal epithelial cells and induced fibroblasts to produce TGF-beta1 that hastened the progression of CKD. |
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Authors:
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Chi-Chen Wei; Hsing-Hui Li; Yu-Hsiang Hsu; Chung-Hsi Hsing; Junne-Ming Sung; Ming-Shi Chang |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2008-07-17 |
Journal Detail:
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Title: Biochemical and biophysical research communications Volume: 374 ISSN: 1090-2104 ISO Abbreviation: Biochem. Biophys. Res. Commun. Publication Date: 2008 Sep |
Date Detail:
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Created Date: 2008-08-15 Completed Date: 2008-09-05 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0372516 Medline TA: Biochem Biophys Res Commun Country: United States |
Other Details:
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Languages: eng Pagination: 448-53 Citation Subset: IM |
Affiliation:
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Institute of Basic Medical Sciences, Medical College, National Cheng Kung University, 138 Sheng-Li Road, Tainan 70428, Taiwan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Apoptosis Cells, Cultured Chronic Disease Disease Models, Animal Epithelial Cells / metabolism, pathology Fibroblasts / metabolism, pathology Humans Interleukins / blood, metabolism* Kidney Diseases / blood, metabolism*, pathology* Kidney Tubules / metabolism*, pathology* Liver / metabolism, pathology Lung Male Mice Myocardium Rats Rats, Sprague-Dawley Tissue Distribution Transforming Growth Factor beta1 / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Interleukins; 0/Transforming Growth Factor beta1; 0/interleukin 20 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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