Document Detail


Interleukin-20 targets renal cells and is associated with chronic kidney disease.
MedLine Citation:
PMID:  18639518     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Interleukin (IL)-10 is an anti-inflammatory factor that suppresses renal fibrosis and improves renal function in CKD rats. IL-20 belongs to the IL-10 family; therefore, we sought to determine whether IL-20 is involved in CKD. CKD patients at stage five expressed significantly higher IL-20 in serum than controls. Immunohistochemical staining demonstrated that more IL-20 protein was expressed in the kidney tubular-epithelial cells, mesangial cells, and immune cells of CKD rats with a 5/6 nephrectomy. The lung, liver, and heart tissue of CKD rats also overexpressed IL-20. Thus, we treated two tubular epithelial cells, TKPTS and M-1 cells, with IL-20 to study its effects on CKD. IL-20 treatment induced apoptosis in these cells via caspase-3 activation. Incubating IL-20 with rat interstitial fibroblasts, NRK-49F cells, upregulated TGF-beta1 production, one key inducer for renal fibrogenesis. Therefore, IL-20 injured renal epithelial cells and induced fibroblasts to produce TGF-beta1 that hastened the progression of CKD.
Authors:
Chi-Chen Wei; Hsing-Hui Li; Yu-Hsiang Hsu; Chung-Hsi Hsing; Junne-Ming Sung; Ming-Shi Chang
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-07-17
Journal Detail:
Title:  Biochemical and biophysical research communications     Volume:  374     ISSN:  1090-2104     ISO Abbreviation:  Biochem. Biophys. Res. Commun.     Publication Date:  2008 Sep 
Date Detail:
Created Date:  2008-08-15     Completed Date:  2008-09-05     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372516     Medline TA:  Biochem Biophys Res Commun     Country:  United States    
Other Details:
Languages:  eng     Pagination:  448-53     Citation Subset:  IM    
Affiliation:
Institute of Basic Medical Sciences, Medical College, National Cheng Kung University, 138 Sheng-Li Road, Tainan 70428, Taiwan.
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MeSH Terms
Descriptor/Qualifier:
Animals
Apoptosis
Cells, Cultured
Chronic Disease
Disease Models, Animal
Epithelial Cells / metabolism,  pathology
Fibroblasts / metabolism,  pathology
Humans
Interleukins / blood,  metabolism*
Kidney Diseases / blood,  metabolism*,  pathology*
Kidney Tubules / metabolism*,  pathology*
Liver / metabolism,  pathology
Lung
Male
Mice
Myocardium
Rats
Rats, Sprague-Dawley
Tissue Distribution
Transforming Growth Factor beta1 / metabolism
Chemical
Reg. No./Substance:
0/Interleukins; 0/Transforming Growth Factor beta1; 0/interleukin 20

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