Document Detail


Interleukin-20 plays a critical role in maintenance and development of psoriasis in the human xenograft transplantation model.
MedLine Citation:
PMID:  18945296     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Interleukin (IL)-20 is a recently discovered cytokine displaying increased levels in psoriatic lesions. Interestingly, IL-20 levels decrease with antipsoriatic treatment, correlating with clinical improvement. However, the role of IL-20 in the aetiology of psoriasis is unknown. OBJECTIVES: In this study, we investigate the effects both of blocking IL-20 signalling in psoriatic plaques and of adding IL-20 to nonlesional psoriasis skin. METHODS: We employed the human skin xenograft transplantation model in which psoriatic plaques and nonlesional keratome skin biopsies obtained from donors with moderate to severe plaque psoriasis were transplanted on to immuno-deficient mice. The transplanted mice were treated with anti-IL-20 antibodies or recombinant human IL-20. RESULTS: We demonstrate that blocking IL-20 signalling with anti-IL-20 antibodies induces psoriasis resolution and inhibits psoriasis induction. We also demonstrate that continuous IL-20 infusion, together with injection of additional nonactivated leucocytes, promotes induction of psoriasis in nonlesional skin from patients with psoriasis. CONCLUSIONS: The results suggest that IL-20 plays a critical role in the induction and maintenance of psoriasis, and IL-20 is suggested as a new possible specific target in psoriasis treatment.
Authors:
K Stenderup; C Rosada; A Worsaae; F Dagnaes-Hansen; T Steiniche; E Hasselager; L F Iversen; S Zahn; H Wöldike; H Lindgreen Holmberg; J Rømer; K Kragballe; J T Clausen; T N Dam
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-10-20
Journal Detail:
Title:  The British journal of dermatology     Volume:  160     ISSN:  1365-2133     ISO Abbreviation:  Br. J. Dermatol.     Publication Date:  2009 Feb 
Date Detail:
Created Date:  2009-02-03     Completed Date:  2009-04-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0004041     Medline TA:  Br J Dermatol     Country:  England    
Other Details:
Languages:  eng     Pagination:  284-96     Citation Subset:  IM    
Affiliation:
Department of Dermatology, Aarhus University Hospital, Dk-8000 Aarhys, Denmark. Karin_Stenderup@email.dk
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Animals
Antibody Specificity / immunology
Cell Proliferation
Humans
Interleukins / antagonists & inhibitors,  immunology,  physiology*
Mice
Mice, SCID
Middle Aged
Psoriasis / drug therapy,  etiology*,  immunology
Recombinant Proteins / immunology
Remission Induction
Signal Transduction / immunology*
Skin Transplantation*
Transplantation, Heterologous
Chemical
Reg. No./Substance:
0/Interleukins; 0/Recombinant Proteins; 0/interleukin 20

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