Document Detail


Interleukin-2 and spontaneous hypertension.
MedLine Citation:
PMID:  1885224     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
There are conflicting reports with regard to the antihypertensive of interleukin-2 in the spontaneously hypertensive rat. Recently, the original claim of a normalization of arterial pressure in the spontaneously hypertensive rat after a single administration of interleukin-2 has been disputed. Therefore, the present study was performed to determine whether the administration of interleukin-2 was effective in attenuating both the development and maintenance of hypertension in the spontaneously hypertensive rat. Both young prehypertensive spontaneously hypertensive rats and adult spontaneously hypertensive rats with established hypertension received a single subcutaneous dose of 5,000 units/kg human recombinant interleukin-2. Arterial pressure was monitored at weekly intervals in both control and treated animals by the tail-cuff technique. Interleukin-2 administered as a one time single injection had no effect on the development of hypertension in the young animals or on the maintenance of hypertension in the adult animals. Interleukin-2 also was administered as a continuous infusion via osmotic minipumps at dose levels of 5,000 and 50,000 units/kg/wk to both young and adult spontaneously hypertensive rats. Continuous administration of interleukin-2 also had no effect on the development or maintenance of spontaneous hypertension. Therefore, this study firmly demonstrates that interleukin-2 has no effect on the onset or maintenance of hypertension in the spontaneously hypertensive rat.
Authors:
D J Dzielak
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Hypertension     Volume:  18     ISSN:  0194-911X     ISO Abbreviation:  Hypertension     Publication Date:  1991 Aug 
Date Detail:
Created Date:  1991-10-08     Completed Date:  1991-10-08     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  7906255     Medline TA:  Hypertension     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  171-5     Citation Subset:  IM    
Affiliation:
Department of Surgery, University of Mississippi Medical Center, Jackson 39216-4505.
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MeSH Terms
Descriptor/Qualifier:
Animals
Blood Pressure / drug effects
Hypertension / drug therapy*
Infusions, Parenteral
Injections, Subcutaneous
Interleukin-2 / pharmacology*
Male
Rats
Rats, Inbred SHR
Rats, Inbred WKY
Recombinant Proteins / pharmacology
Chemical
Reg. No./Substance:
0/Interleukin-2; 0/Recombinant Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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