Document Detail

Interleukin-2 serum levels variations in recent onset atrial fibrillation are related with cardioversion outcome.
MedLine Citation:
PMID:  17923414     Owner:  NLM     Status:  MEDLINE    
We evaluated the hypothesis that a relationship exists between inflammation and the outcome of pharmaceutical cardioversion with amiodarone in recent onset atrial fibrillation. We studied 86 patients with symptomatic recent onset AF and coexisting hypertension and/or chronic stable coronary artery disease. All study participants underwent evaluation with a standardized protocol including echocardiography, cytokine level measurement [interleukin-2 (IL-2), interleukin-6 (IL-6) and high sensitivity C reactive protein (hsCRP)] on admission and at 48h, and administration of intravenous amiodarone. By 48h, 70 patients cardioverted to sinus rhythm. Median serum IL-2 levels on admission were higher in non-cardioverted compared to cardioverted patients (P=0.002). At 48h, non-cardioverted had significantly higher IL-6 (P=0.005) and hsCRP values (P=0.001) compared to cardioverted. Multivariate logistic regression analysis showed that lower IL-2 admission levels were a powerful independent predictor for successful cardioversion (OR: 0.154, 95% CI: 0.043-0.552, P=0.004). In patients with hypertension and/or chronic stable coronary artery disease and symptomatic recent onset AF, low serum IL-2 levels on admission are associated with successful cardioversion with amiodarone. This observation highlights the role of inflammation in AF and might have further prognostic and therapeutic implications.
Ioannis Rizos; Sotirios Tsiodras; Angelos G Rigopoulos; Spiros Dragomanovits; Andreas S Kalogeropoulos; Sotirios Papathanasiou; Eleftherios A Sakadakis; Dimitrios Th Kremastinos
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Publication Detail:
Type:  Journal Article     Date:  2007-10-17
Journal Detail:
Title:  Cytokine     Volume:  40     ISSN:  1096-0023     ISO Abbreviation:  Cytokine     Publication Date:  2007 Dec 
Date Detail:
Created Date:  2007-12-10     Completed Date:  2008-03-25     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9005353     Medline TA:  Cytokine     Country:  United States    
Other Details:
Languages:  eng     Pagination:  157-64     Citation Subset:  IM    
2nd Academic Department of Cardiology, Attikon University Hospital, University of Athens Medical School, 19 Kentauron Street, 15237 Filothei, Athens, Greece.
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MeSH Terms
Aged, 80 and over
Amiodarone / administration & dosage*
Anti-Arrhythmia Agents / administration & dosage*
Atrial Fibrillation / blood*,  complications,  drug therapy*,  physiopathology
C-Reactive Protein / analysis
Chronic Disease
Coronary Artery Disease / blood,  complications,  drug therapy,  physiopathology
Cross-Sectional Studies
Enoxaparin / administration & dosage
Fibrinolytic Agents / administration & dosage
Hypertension / blood,  complications,  drug therapy,  physiopathology
Inflammation / blood,  complications,  drug therapy,  physiopathology
Infusions, Intravenous
Interleukin-2 / blood*
Interleukin-6 / blood
Predictive Value of Tests
Remission Induction
Time Factors
Reg. No./Substance:
0/Anti-Arrhythmia Agents; 0/Enoxaparin; 0/Fibrinolytic Agents; 0/IL6 protein, human; 0/Interleukin-2; 0/Interleukin-6; 1951-25-3/Amiodarone; 9007-41-4/C-Reactive Protein

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