| Interleukin 2 receptor-targeted therapy--rationale and applications in organ transplantation. | |
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MedLine Citation:
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PMID: 2462756 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Despite major advances in immunopharmacology for use in clinical organ transplantation, graft rejection and drug-induced side effects remain the major problems with currently available immunosuppressive modalities. Recent advances in hybridoma technology have produced relatively effective and reproducible biological immunosuppression with monoclonal antibodies; indeed, OKT3 and anti-T12 mAbs have been employed with considerable success as adjuncts to chemical suppression in treating rejection. Nonetheless, the use of such antibodies broadly reactive to differentiation antigens on T lymphocytes does not solve the problems of side effects caused by general immunosuppression. An ideal therapeutic agent should target only lymphocytes that participate in rejection of foreign tissue without affecting physiological host immune surveillance and normal defense mechanisms. Theoretically, this goal could be achieved by "antigenic suicide," or by using the appropriate antiidiotypic antibodies or mAbs against the antigen combining site of T cell receptors. However, because of the intense polymorphism of transplantation antigens and the vast genetic repertoire encoding for the T cell antigen receptor, success of such forms of specific immunosuppression, at least at this time, is highly improbable. |
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Authors:
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J W Kupiec-Weglinski; T Diamantstein; N L Tilney |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Review |
Journal Detail:
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Title: Transplantation Volume: 46 ISSN: 0041-1337 ISO Abbreviation: Transplantation Publication Date: 1988 Dec |
Date Detail:
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Created Date: 1989-02-06 Completed Date: 1989-02-06 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0132144 Medline TA: Transplantation Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 785-92 Citation Subset: IM |
Affiliation:
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Surgical Research Laboratory, Harvard Medical School, Boston, MA 02115. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antibodies, Monoclonal / therapeutic use* Antigens, Differentiation, T-Lymphocyte / immunology Epitopes / immunology Graft Rejection Humans Immunosuppression / methods* Kidney Transplantation Lymphocyte Activation Macaca Mice Papio Receptors, Interleukin-2 / immunology* Transplantation Immunology* |
| Grant Support | |
ID/Acronym/Agency:
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R01 AI19071/AI/NIAID NIH HHS; R01 AI23847/AI/NIAID NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Antibodies, Monoclonal; 0/Antigens, Differentiation, T-Lymphocyte; 0/Epitopes; 0/Receptors, Interleukin-2 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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