| Interleukin-2 receptor serum concentrations in normal pregnancy and pre-eclampsia. | |
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MedLine Citation:
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PMID: 12108028 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The purpose of this research was to assess interleukin-2 receptor serum levels in normal pregnancy and pre-eclampsia. Sera from 90 healthy pregnant women (30 for each trimester), 30 with pre-eclampsia and a group of 30 healthy non-pregnant were analyzed. Soluble interleukin-2 receptor was measured by specific double antibody enzymatic immunoassay (ELISA). Results were: 267.5 +/- 12.3 (mean +/- s.e.m) pg/mL in the uncomplicated first trimester sample, 300.9 +/- 14.5 pg/mL in the second trimester and 248.8 +/- 12.5 pg/mL in the third. The non-pregnant control group had 443.7 +/- 39.6 pg/mL, significantly different from normal pregnancy in all trimesters (p < 0.001). The concentration in pre-eclamptic patients was 382.2 +/- 24.2 pg/mL, with p < 0.01 with regard to the normal third trimester group. The conclusion is that interleukin-2 receptor serum levels diminish in normal pregnancy and rise in preeclampsia. The first finding seems to be a protective mechanism to the fetal allograft. The latter, point to increased cellular activity. |
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Authors:
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Tania Romero-Adrián; Ana Ruiz; Rafael Molina-Vílchez; Jesús Estévez; Ricardo Atencio |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Investigación clínica Volume: 43 ISSN: 0535-5133 ISO Abbreviation: Invest Clin Publication Date: 2002 Jun |
Date Detail:
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Created Date: 2002-07-10 Completed Date: 2002-09-03 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0421531 Medline TA: Invest Clin Country: Venezuela |
Other Details:
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Languages: eng Pagination: 73-8 Citation Subset: IM |
Affiliation:
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Facultad de Medicina, Universidad del Zulia, Maracaibo, Venezuela. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Female Humans Pre-Eclampsia / blood* Pregnancy / blood* Pregnancy Trimesters Receptors, Interleukin-1 / blood* Solubility |
| Chemical | |
Reg. No./Substance:
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0/Receptors, Interleukin-1 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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