Document Detail

Interleukin-2 production of lymphocytes in food sensitive atopic dermatitis.
MedLine Citation:
PMID:  1575549     Owner:  NLM     Status:  MEDLINE    
The proliferative responses of peripheral blood mononuclear cells (PBMC) to food antigens in 22 patients with food sensitive atopic dermatitis were significantly higher than the responses of healthy children and food sensitive children with immediate symptoms. Moreover, the activity of interleukin-2 (IL-2) in supernatants of food antigen stimulated PBMC cultures from patients with atopic dermatitis was significantly higher than that in healthy children and food sensitive children with immediate symptoms. The activity of IL-2 in culture supernatants of separated cell populations stimulated with food antigens from patients with atopic dermatitis and healthy children was investigated. The activity of IL-2 in supernatants of food antigen stimulated T cell cultures could be detected in patients with atopic dermatitis but not in healthy children. These results suggest that the increased IL-2 production after food antigen stimulation is due to increased T cell activity in food sensitive atopic dermatitis.
H Agata; N Kondo; O Fukutomi; S Shinoda; T Orii
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Archives of disease in childhood     Volume:  67     ISSN:  1468-2044     ISO Abbreviation:  Arch. Dis. Child.     Publication Date:  1992 Mar 
Date Detail:
Created Date:  1992-05-29     Completed Date:  1992-05-29     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0372434     Medline TA:  Arch Dis Child     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  280-4     Citation Subset:  AIM; IM    
Department of Paediatrics, Gifu University School of Medicine, Japan.
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MeSH Terms
B-Lymphocytes / immunology
Child, Preschool
Dermatitis, Atopic / blood,  immunology*
Food Hypersensitivity / blood,  immunology*
Interleukin-2 / immunology*
Leukocytes, Mononuclear / immunology*
Lymphocyte Activation*
Radioallergosorbent Test
T-Lymphocytes / immunology
Reg. No./Substance:
Comment In:
Arch Dis Child. 1992 Nov;67(11):1413   [PMID:  1471905 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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