Document Detail


Interleukin 2 production in lymphocyte cultures: a rapid test for cancer-associated immunodeficiency in malignant cervical neoplasia.
MedLine Citation:
PMID:  2699725     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Peripheral blood lymphocytes of patients with malignant cervical neoplasia were studied for their capacity to produce interleukin-2 (IL-2) upon in vitro mitogen stimulation. Patients with early disease (Stage I/IIA) showed levels comparable to normal controls but those with advanced disease showed reduced levels, the reduction increasing with tumour load. These findings excellently correlated with our previous observations on a depressed cellular immunity in these patients. On follow up of the patients it was noticed that those who developed recurrent disease showed sustained lower levels of IL-2 production compared to those who remained disease free. These results stress the importance of a deranged immune system in these patients and also shows the clinical and prognostic value of such an assay.
Authors:
M Radhakrishna Pillai; P Balaram; S Bindu; N K Hareendran; T K Padmanabhan; M K Nair
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Cancer letters     Volume:  47     ISSN:  0304-3835     ISO Abbreviation:  Cancer Lett.     Publication Date:  1989 Oct 
Date Detail:
Created Date:  1990-06-18     Completed Date:  1990-06-18     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7600053     Medline TA:  Cancer Lett     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  205-10     Citation Subset:  IM    
Affiliation:
Division of Cancer Research, Regional Cancer Center, Trivandrum, India.
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MeSH Terms
Descriptor/Qualifier:
Carcinoma, Squamous Cell / immunology*,  pathology,  radiotherapy
Female
Follow-Up Studies
Humans
Immunity, Cellular
Immunologic Techniques
Interleukin-2 / biosynthesis*
Lymphocyte Activation
Lymphocytes / immunology*
Neoplasm Recurrence, Local / immunology
Neoplasm Staging
Prognosis
Uterine Cervical Neoplasms / immunology*,  pathology,  radiotherapy
Chemical
Reg. No./Substance:
0/Interleukin-2

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