Document Detail

Interleukin 2 production by alloantigen (H-2) activated T cells.
MedLine Citation:
PMID:  6975098     Owner:  NLM     Status:  MEDLINE    
H-2 alloantigen-activated T cells release Interleukin 2 in response to a secondary stimulus by either Concanavalin A or alloantigen. No detectable lymphokine is released in the absence of secondary stimulation and, in the case of alloantigen restimulation, lymphokine release is antigen-specific. Once formed, however, the lymphokine shows no antigen specificity in its action. Like the precursor of the cytotoxic T cell, the precursor of the Interleukin 2-producing T cell requires two signals for its activation; alloantigen and a source of costimulator activity. Once activated, T cells will release lymphokine in response to alloantigen alone.
L Andrus; K J Lafferty
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Australian journal of experimental biology and medical science     Volume:  59     ISSN:  0004-945X     ISO Abbreviation:  Aust J Exp Biol Med Sci     Publication Date:  1981 Aug 
Date Detail:
Created Date:  1981-12-15     Completed Date:  1981-12-15     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0416662     Medline TA:  Aust J Exp Biol Med Sci     Country:  AUSTRALIA    
Other Details:
Languages:  eng     Pagination:  413-26     Citation Subset:  IM    
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MeSH Terms
Antibodies, Monoclonal
Concanavalin A
H-2 Antigens*
Interleukin-2 / biosynthesis*
Lymphocyte Activation*
Lymphokines / biosynthesis*
Mice, Inbred Strains
Neoplasms, Experimental / immunology
T-Lymphocytes / immunology*
Reg. No./Substance:
0/Antibodies, Monoclonal; 0/H-2 Antigens; 0/Interleukin-2; 0/Lymphokines; 11028-71-0/Concanavalin A

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