| Interleukin-2 inhalation therapy in renal cell cancer: a case report and review of the literature. | |
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MedLine Citation:
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PMID: 18712176 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Renal cell carcinoma (RCC) is the most common malignancy of the kidney. One third of RCC presents metastatic disease at the time of diagnosis, usually leading to a fatal outcome. Small response rates were seen with most cytotoxic agents including gemcitabine and vinorelbine, whereas systemic therapy with high doses of interleukin 2 (IL-2) has been shown to provide durable complete remissions. However, in consideration of its severe toxicity, IL-2 immunotherapy is restricted to selected patients. Aerosol IL-2 has been introduced as an alternative therapy in cancer patients. However, only very few data are available on its use in patients with pulmonary metastatic RCC. This paper briefly summarizes current clinical experience with the use of inhaled IL-2 therapy, either as a single therapy or in combination with other treatments. In addition, we report on a male patient with pulmonary metastasized RCC who achieved a durable complete response to combined gemcitabine/vinorelbine and interleukin-2 inhalation therapy. |
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Authors:
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Girolamo Del Monte; Patrizia Ferroni; Sabrina Mariotti; Emanuela Fossile; Fiorella Guadagni; Mario Roselli |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: In vivo (Athens, Greece) Volume: 22 ISSN: 0258-851X ISO Abbreviation: In Vivo Publication Date: 2008 Jul-Aug |
Date Detail:
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Created Date: 2008-08-20 Completed Date: 2008-09-19 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8806809 Medline TA: In Vivo Country: Greece |
Other Details:
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Languages: eng Pagination: 481-8 Citation Subset: IM |
Affiliation:
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Medical Oncology, Department of Internal Medicine, University of Rome Tor Vergata, Tor Vergata Clinical Center, Rome, Italy. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Antineoplastic Combined Chemotherapy Protocols / therapeutic use* Carcinoma, Renal Cell / metabolism* Deoxycytidine / administration & dosage, analogs & derivatives Gene Expression Regulation, Neoplastic* Humans Immunotherapy / methods Interleukin-2 / administration & dosage* Kidney Neoplasms / metabolism* Male Neoplasm Metastasis Tomography, X-Ray Computed Treatment Outcome Vinblastine / administration & dosage, analogs & derivatives |
| Chemical | |
Reg. No./Substance:
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0/Interleukin-2; 103882-84-4/gemcitabine; 71486-22-1/vinorelbine; 865-21-4/Vinblastine; 951-77-9/Deoxycytidine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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