Document Detail

Interleukin-2 in human amniotic fluid during pregnancy and parturition: implications for prostaglandin E2 release by fetal membranes.
MedLine Citation:
PMID:  8636925     Owner:  NLM     Status:  MEDLINE    
The potential role of interleukin 2 (IL-2) in human pregnancy was investigated by evaluating the following. (1) The presence and concentrations of IL-2 in amniotic fluid (AF) in 24 women at 16-18 weeks' gestation (Group 1) and in 27 women at term pregnancy, either before the onset of labor (Group 2, n = 10) or during spontaneous active labor (Group 3, n = 17). (2) The production of IL-2 by fetal membranes at term gestation (n = 7). (3) The release of prostaglandin E2 (PGE2) by the above tissues after stimulation with IL-2 (n = 10) or phytohemagglutinin (PHA) (n = 8). Immunoreactive IL-2 was detected only in AF samples obtained from women of Groups 1 and 3; the higher concentration was found in Group 1 samples; IL-2 was not detected in AF samples from women of Group 2. Tissues did not release IL-2. Both IL-2 and PHA exerted a significant stimulatory effect on PGE2 release by tissues. IL-2 stimulated PGE2 release by chorion tissue, but not by amnion tissue. The following conclusions can be drawn: (a) AF IL-2 might play a role in the maternal-fetal immune relationship during early pregnancy and, perhaps, during labor; (b) fetal membranes would not seem to represent a source of AF IL-2 in the absence of labor; (3) IL-2 might influence arachidonic acid metabolism through the cyclooxygenase pathway in the chorion tissue.
A Zicari; C Ticconi; N Pasetto; A Losardo; A Salerno; G Pontieri; E Piccone
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of reproductive immunology     Volume:  29     ISSN:  0165-0378     ISO Abbreviation:  J. Reprod. Immunol.     Publication Date:  1995 Oct 
Date Detail:
Created Date:  1996-07-05     Completed Date:  1996-07-05     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  8001906     Medline TA:  J Reprod Immunol     Country:  IRELAND    
Other Details:
Languages:  eng     Pagination:  197-208     Citation Subset:  IM    
Department of Experimental Medicine and Pathology, University 'La Sapienza', Rome, Italy.
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MeSH Terms
Amniotic Fluid / chemistry*
Dinoprostone / secretion*
Extraembryonic Membranes / secretion*
Interleukin-2 / analysis,  pharmacology,  physiology*
Labor, Obstetric / metabolism*
Phytohemagglutinins / pharmacology
Reg. No./Substance:
0/Interleukin-2; 0/Phytohemagglutinins; 363-24-6/Dinoprostone

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