| Interleukin-2 as a neuromodulator possibly implicated in the physiopathology of sudden infant death syndrome. | |
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MedLine Citation:
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PMID: 20542085 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Dysfunction in vital brainstem centers, including those controlling cardiorespiratory- and sleep/arousal pathophysiology, is reported in sudden infant death syndrome (SIDS). Biological mechanisms underlying SIDS, however, remain unclear. Cytokines are inter-cellular signaling chemicals. They can interact with neurotransmitters and might thus modify neural and neuroimmune functions. Cytokines could therefore act as neuromodulators. Interleukin (IL)-2 is a major immune-related cytokine. It has not been previously depicted in vital brainstem centers. We detected intense neuronal IL-2 immune-reactivity in the SIDS brainstem, namely in vital neural centers. This IL-2 overexpression might interfere with neurotransmitters in those critical brainstem centers, causing disturbed homeostatic control of cardiorespiratory and arousal responses, possibly leading to SIDS. |
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Authors:
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Hazim Kadhim; Paul Deltenre; Carine De Prez; Guillaume Sébire |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-06-11 |
Journal Detail:
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Title: Neuroscience letters Volume: 480 ISSN: 1872-7972 ISO Abbreviation: Neurosci. Lett. Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-07-13 Completed Date: 2010-10-19 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7600130 Medline TA: Neurosci Lett Country: Ireland |
Other Details:
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Languages: eng Pagination: 122-6 Citation Subset: IM |
Copyright Information:
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Copyright 2010 Elsevier Ireland Ltd. All rights reserved. |
Affiliation:
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Neuropathology Unit, Department of Anatomic Pathology, Centre Hospitalier Universitaire Brugmann, Université Libre de Bruxelles (U.L.B.), Place van Gehuchten 4, 1020 Brussels, Belgium. Hazim.Kadhim@chu-brugmann.be |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Brain Stem
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metabolism*,
pathology Female Humans Infant Interleukin-2 / metabolism* Male Neuroimmunomodulation* Sudden Infant Death / immunology*, pathology |
| Chemical | |
Reg. No./Substance:
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0/Interleukin-2 |
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