Document Detail


Interleukin-2 as a neuromodulator possibly implicated in the physiopathology of sudden infant death syndrome.
MedLine Citation:
PMID:  20542085     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Dysfunction in vital brainstem centers, including those controlling cardiorespiratory- and sleep/arousal pathophysiology, is reported in sudden infant death syndrome (SIDS). Biological mechanisms underlying SIDS, however, remain unclear. Cytokines are inter-cellular signaling chemicals. They can interact with neurotransmitters and might thus modify neural and neuroimmune functions. Cytokines could therefore act as neuromodulators. Interleukin (IL)-2 is a major immune-related cytokine. It has not been previously depicted in vital brainstem centers. We detected intense neuronal IL-2 immune-reactivity in the SIDS brainstem, namely in vital neural centers. This IL-2 overexpression might interfere with neurotransmitters in those critical brainstem centers, causing disturbed homeostatic control of cardiorespiratory and arousal responses, possibly leading to SIDS.
Authors:
Hazim Kadhim; Paul Deltenre; Carine De Prez; Guillaume Sébire
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-06-11
Journal Detail:
Title:  Neuroscience letters     Volume:  480     ISSN:  1872-7972     ISO Abbreviation:  Neurosci. Lett.     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-07-13     Completed Date:  2010-10-19     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7600130     Medline TA:  Neurosci Lett     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  122-6     Citation Subset:  IM    
Copyright Information:
Copyright 2010 Elsevier Ireland Ltd. All rights reserved.
Affiliation:
Neuropathology Unit, Department of Anatomic Pathology, Centre Hospitalier Universitaire Brugmann, Université Libre de Bruxelles (U.L.B.), Place van Gehuchten 4, 1020 Brussels, Belgium. Hazim.Kadhim@chu-brugmann.be
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MeSH Terms
Descriptor/Qualifier:
Brain Stem / metabolism*,  pathology
Female
Humans
Infant
Interleukin-2 / metabolism*
Male
Neuroimmunomodulation*
Sudden Infant Death / immunology*,  pathology
Chemical
Reg. No./Substance:
0/Interleukin-2

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