| Interleukin-2 receptor signaling: at the interface between tolerance and immunity. | |
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MedLine Citation:
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PMID: 20732639 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Interleukin-2 receptor (IL-2R) signaling regulates tolerance and immunity. Here, we review recent work concerning the structure, signaling, and function of the IL-2R, emphasizing the contribution of IL-2 for T cell-dependent activity in vivo. IL-2R signaling influences two discrete aspects of immune responses by CD8(+) T cells, terminal differentiation of effector cells in primary responses, and aspects of memory recall responses. IL-2 also delivers essential signals for thymic development of regulatory T (Treg) cells and later to promote their homeostasis and function. Each of these outcomes on T effector and Treg cells requires distinct amounts of IL-2R signaling, with low IL-2R signaling sufficient for many key aspects of Treg cells. Thus, tolerance is readily maintained and favored with limited IL-2. |
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Authors:
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Thomas R Malek; Iris Castro |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Review |
Journal Detail:
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Title: Immunity Volume: 33 ISSN: 1097-4180 ISO Abbreviation: Immunity Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-08-24 Completed Date: 2010-09-08 Revised Date: 2011-08-30 |
Medline Journal Info:
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Nlm Unique ID: 9432918 Medline TA: Immunity Country: United States |
Other Details:
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Languages: eng Pagination: 153-65 Citation Subset: IM |
Copyright Information:
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Copyright 2010 Elsevier Inc. All rights reserved. |
Affiliation:
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Department of Microbiology and Immunology, Miller School of Medicine, University of Miami, PO Box 01960, Miami, FL 33101, USA. tmalek@med.miami.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Humans Immune Tolerance* Immunity* Immunologic Memory Receptors, Interleukin-2 / immunology*, metabolism Signal Transduction* T-Lymphocytes / cytology, immunology |
| Grant Support | |
ID/Acronym/Agency:
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3R56AI40114/AI/NIAID NIH HHS; P01 CA109094-040001/CA/NCI NIH HHS; P01CA109094/CA/NCI NIH HHS; R01 AI055815-05/AI/NIAID NIH HHS; R01 CA045957-23/CA/NCI NIH HHS; R01AI055815/AI/NIAID NIH HHS; R01CA45957/CA/NCI NIH HHS; R56 AI040114-11A1S1/AI/NIAID NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Receptors, Interleukin-2 |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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