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Interleukin 2 (IL-2)-induced tyrosine phosphorylation of IL-2 receptor p75.
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MedLine Citation:
PMID:  2106566     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We have recently established a mAb named TU11 mAb specific for the p75 subunit of human IL-2 receptor (IL-2R). The present study using TU11 mAb demonstrates the IL-2-induced phosphorylation of IL-2Rp75 on tyrosine residues in IL-2-dependent T cells. The tyrosine phosphorylation is mediated by the high affinity IL-2R, correlates with the IL-2-induced cell growth, and rapidly increases during the first 5 min of IL-2 stimulation. Phosphorylation of serine and threonine residues of IL-2Rp75 is also detected, but its IL-2 dependency is not significant during at least the first 5 min. These results suggest some roles of a tyrosine kinase associated with IL-2Rp75 in the IL-2-induced signal-transducing pathway.
Authors:
H Asao; T Takeshita; M Nakamura; K Nagata; K Sugamura
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of experimental medicine     Volume:  171     ISSN:  0022-1007     ISO Abbreviation:  J. Exp. Med.     Publication Date:  1990 Mar 
Date Detail:
Created Date:  1990-04-12     Completed Date:  1990-04-12     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  2985109R     Medline TA:  J Exp Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  637-44     Citation Subset:  IM    
Affiliation:
Department of Microbiology, Tohoku University School of Medicine, Sendai, Japan.
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MeSH Terms
Descriptor/Qualifier:
Humans
Interleukin-2 / pharmacology*
Phosphorylation
Protein-Tyrosine Kinases / physiology
Receptors, Interleukin-2 / metabolism*
Threonine / metabolism
Tyrosine / metabolism*
Chemical
Reg. No./Substance:
0/Interleukin-2; 0/Receptors, Interleukin-2; 55520-40-6/Tyrosine; 72-19-5/Threonine; EC 2.7.10.1/Protein-Tyrosine Kinases
Comments/Corrections
Erratum In:
J Exp Med 1990 Jun 1;171(6):2183

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Full Text
Journal Information
Journal ID (nlm-ta): J Exp Med
ISSN: 0022-1007
ISSN: 1540-9538
Publisher: The Rockefeller University Press
Article Information
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Print publication date: Day: 1 Month: 3 Year: 1990
Volume: 171 Issue: 3
First Page: 637 Last Page: 644
ID: 2187791
Publisher Id: 90171833
PubMed Id: 2106566

Interleukin 2 (IL-2)-induced tyrosine phosphorylation of IL-2 receptor p75 [published erratum appears in J Exp Med 1990 Jun 1;171(6):2183]


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