| Interleukin-1beta, interleukin-18, and interferon-gamma expression in the cerebrospinal fluid of premature infants with posthemorrhagic hydrocephalus--markers of white matter damage? | |
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MedLine Citation:
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PMID: 17426654 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Posthemorrhagic hydrocephalus (PHHC) represents a major complication of preterm birth. The aim of this study was to determine whether cerebrospinal fluid (CSF) levels of the pro-inflammatory cytokines IL-1beta, IL-18, and interferon (IFN)-gamma are altered in the CSF of preterm infants with PHHC and may serve as a marker of white matter damage (WMD). Twenty-seven preterm infants with PHHC were included in the study; 13 of them had signs of cystic WMD (cWMD) on ultrasound examinations. CSF sample 1 was obtained at first ventriculostomy, sample 2 at shunt implantation. Results were compared with a control group of 20 age-matched patients without neurologic diseases. IL-1beta concentrations were elevated in CSF sample 1 of PHHC patients without WMD and in sample 1 of patients with cWMD. Concentrations of IL-18 were increased in both samples of patients without WMD and in sample 2 of patients with cWMD. CSF levels of IFN-gamma were elevated in sample 1 of PHHC patients with cWMD. The pro-inflammatory cytokine IL-1beta and IL-18 levels in the CSF are elevated in patients with PHHC. Higher IFN-gamma levels are detected in a subgroup of patients developing cWMD, indicating its involvement in the pathogenesis of cWMD in the context of PHHC. |
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Authors:
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Thomas Schmitz; Axel Heep; Floris Groenendaal; Dieter Hüseman; Susanne Kie; Peter Bartmann; Michael Obladen; Ursula Felderhoff-Müser |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Pediatric research Volume: 61 ISSN: 0031-3998 ISO Abbreviation: Pediatr. Res. Publication Date: 2007 Jun |
Date Detail:
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Created Date: 2007-08-23 Completed Date: 2007-10-04 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 0100714 Medline TA: Pediatr Res Country: United States |
Other Details:
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Languages: eng Pagination: 722-6 Citation Subset: IM |
Affiliation:
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Department of Neonatology, Campus Virchow Klinikum, Charité - Universitätsmedizin Berlin, 13353 Berlin, Germany. thomas.schmitz@charite.de |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Biological Markers
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cerebrospinal fluid Cerebral Hemorrhage / complications* Female Humans Hydrocephalus / etiology, pathology*, ultrasonography Infant, Newborn Infant, Premature / cerebrospinal fluid* Interferon-gamma / cerebrospinal fluid* Interleukin-18 / cerebrospinal fluid* Interleukin-1beta / cerebrospinal fluid* Male |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Interleukin-18; 0/Interleukin-1beta; 82115-62-6/Interferon-gamma |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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