Document Detail

Interleukin-1beta, interleukin-18, and interferon-gamma expression in the cerebrospinal fluid of premature infants with posthemorrhagic hydrocephalus--markers of white matter damage?
MedLine Citation:
PMID:  17426654     Owner:  NLM     Status:  MEDLINE    
Posthemorrhagic hydrocephalus (PHHC) represents a major complication of preterm birth. The aim of this study was to determine whether cerebrospinal fluid (CSF) levels of the pro-inflammatory cytokines IL-1beta, IL-18, and interferon (IFN)-gamma are altered in the CSF of preterm infants with PHHC and may serve as a marker of white matter damage (WMD). Twenty-seven preterm infants with PHHC were included in the study; 13 of them had signs of cystic WMD (cWMD) on ultrasound examinations. CSF sample 1 was obtained at first ventriculostomy, sample 2 at shunt implantation. Results were compared with a control group of 20 age-matched patients without neurologic diseases. IL-1beta concentrations were elevated in CSF sample 1 of PHHC patients without WMD and in sample 1 of patients with cWMD. Concentrations of IL-18 were increased in both samples of patients without WMD and in sample 2 of patients with cWMD. CSF levels of IFN-gamma were elevated in sample 1 of PHHC patients with cWMD. The pro-inflammatory cytokine IL-1beta and IL-18 levels in the CSF are elevated in patients with PHHC. Higher IFN-gamma levels are detected in a subgroup of patients developing cWMD, indicating its involvement in the pathogenesis of cWMD in the context of PHHC.
Thomas Schmitz; Axel Heep; Floris Groenendaal; Dieter Hüseman; Susanne Kie; Peter Bartmann; Michael Obladen; Ursula Felderhoff-Müser
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Pediatric research     Volume:  61     ISSN:  0031-3998     ISO Abbreviation:  Pediatr. Res.     Publication Date:  2007 Jun 
Date Detail:
Created Date:  2007-08-23     Completed Date:  2007-10-04     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0100714     Medline TA:  Pediatr Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  722-6     Citation Subset:  IM    
Department of Neonatology, Campus Virchow Klinikum, Charité - Universitätsmedizin Berlin, 13353 Berlin, Germany.
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MeSH Terms
Biological Markers / cerebrospinal fluid
Cerebral Hemorrhage / complications*
Hydrocephalus / etiology,  pathology*,  ultrasonography
Infant, Newborn
Infant, Premature / cerebrospinal fluid*
Interferon-gamma / cerebrospinal fluid*
Interleukin-18 / cerebrospinal fluid*
Interleukin-1beta / cerebrospinal fluid*
Reg. No./Substance:
0/Biological Markers; 0/Interleukin-18; 0/Interleukin-1beta; 82115-62-6/Interferon-gamma

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