| Interleukin-1beta-induced fever in young and old Long-Evans rats. | |
| | |
MedLine Citation:
|
PMID: 9791084 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Aging is associated with a blunted or absent fever response to naturally occurring infections or to the peripheral administration of bacterial products and proinflammatory cytokines, including interleukin-1beta (IL-1beta). Whether old rats also exhibit an attenuated fever response when challenged with direct brain administration of IL-1beta is unknown. Here we investigated the fever response of young (3-5 mo) and old (24-26 mo) Long-Evans rats to the intracerebroventricular microinfusion of IL-1beta. Core body temperature was monitored by telemetry in freely moving rats. Intracerebroventricularly administered IL-1beta induced comparable increases in body temperature in young and old Long-Evans rats. In the two groups, IL-1beta-induced fever was similar both in latency to peak fever and maximal fever response, whether the cytokine was administered 2 h after lights on or just before lights off. These data show that old Long-Evans rats are not defective in their capacity to develop a fever in response to brain administration of IL-1beta. |
| | |
Authors:
|
C R Plata-Salamán; E Peloso; E Satinoff |
Related Documents
:
|
7938244 - Reductions in body temperature and spontaneous activity in rats exposed to horizontal r... 18597914 - Post-cardiac arrest temperature manipulation alters early eeg bursting in rats. 12838424 - Involvement of the parabrachial nucleus in thermogenesis induced by environmental cooli... 6634974 - Schedule-induced polydipsia as a function of percent of body weight in the mongolian ge... 2820914 - The use of rats associated with a human faecal flora as a model for studying the effect... 2968794 - Free and bound forms of atrial natriuretic peptide (anp) in rat plasma: preferential in... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
|
Title: The American journal of physiology Volume: 275 ISSN: 0002-9513 ISO Abbreviation: Am. J. Physiol. Publication Date: 1998 Nov |
Date Detail:
|
Created Date: 1998-12-10 Completed Date: 1998-12-10 Revised Date: 2007-11-14 |
Medline Journal Info:
|
Nlm Unique ID: 0370511 Medline TA: Am J Physiol Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: R1633-8 Citation Subset: IM |
Affiliation:
|
Department of Biological Sciences, University of Delaware, Newark, Delaware 19716-2590, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Age Factors Animals Body Temperature / drug effects* Circadian Rhythm Fever / chemically induced*, immunology Injections, Intraventricular Interleukin-1 / administration & dosage* Male Rats Rats, Long-Evans |
| Grant Support | |
ID/Acronym/Agency:
|
R01-MH41138/MH/NIMH NIH HHS; R01-MH56082/MH/NIMH NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Interleukin-1 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Leptin increases energy expenditure of a marsupial by inhibition of daily torpor.
Next Document: Evidence that brain angiotensin II is involved in both thirst and sodium appetite in baboons.