| Interleukin-1beta in the bronchoalveolar lavage fluid of premature neonates: a marker for maternal chorioamnionitis and predictor of adverse neonatal outcome. | |
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MedLine Citation:
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PMID: 14694976 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To determine whether the presence of the proinflammatory cytokine interleukin (IL)-1beta in the lungs of preterm infants immediately after birth was associated with maternal inflammation and could predict adverse neonatal outcome. STUDY DESIGN: Prospective evaluation of serially obtained tracheal aspirates for the presence of IL-1beta in 25 preterm infants (birth weight 595-1700 g; gestational age 24-32 weeks) with respiratory distress syndrome. The initial tracheal aspirate was obtained within 1 h after delivery. RESULTS: An initial tracheal aspirate positive for IL-1beta had a highly significant correlation with documented maternal chorioamnionitis for the given patient. In addition, the presence of IL-1beta correlated significantly with elevated total cell count (2.62 vs. 0.96 x 10(6)/ml, p = 0.0097), granulocyte count (2.12 vs. 0.22 x 10(6)/ml, p = 0.001), macrophage count (0.28 vs. 0.01 x 10(6)/ml, p = 0.02) and the presence of proinflammatory cytokines IL-6, IL-8 and tumor necrosis factor (TNF)-alpha. Preterm neonates positive for IL-1beta in their initial sample were on prolonged assisted ventilation (38 vs. 16 days, p = 0.013) and oxygen supplementation (62 vs. 40.5 days, p = 0.0462) and required prolonged hospitalization (69 vs. 46 days, p = 0.0165). CONCLUSIONS: The concentration of IL-1beta in the initial tracheal aspirate obtained from the lungs of preterm infants within the first hour of life may serve as a marker of antenatal/perinatal inflammation, probably due to maternal chorioamnionitis, and could predict an adverse clinical course and short-term outcome. |
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Authors:
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R G Cayabyab; C A Jones; K Y C Kwong; C Hendershott; C Lecart; P Minoo; R Ramanathan |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians Volume: 14 ISSN: 1476-7058 ISO Abbreviation: J. Matern. Fetal. Neonatal. Med. Publication Date: 2003 Sep |
Date Detail:
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Created Date: 2003-12-25 Completed Date: 2004-03-04 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 101136916 Medline TA: J Matern Fetal Neonatal Med Country: United States |
Other Details:
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Languages: eng Pagination: 205-11 Citation Subset: IM |
Affiliation:
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Division of Neonatology and Allergy/Immunology, Department of Pediatrics, Women's and Children's Hospital, LAC and USC Medical Center, University of Southern California School of Medicine, Los Angeles, California 90033, USA. |
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| MeSH Terms | |
Descriptor/Qualifier:
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Biological Markers
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analysis Bronchoalveolar Lavage Fluid / cytology* Cesarean Section / utilization Chorioamnionitis / immunology* Cytokines / metabolism Female Humans Infant, Newborn Infant, Premature / metabolism* Interleukin-1 / metabolism* Intubation, Intratracheal Length of Stay / statistics & numerical data Male Outcome Assessment (Health Care) Oxygen Inhalation Therapy Pregnancy Prospective Studies Respiration, Artificial Respiratory Distress Syndrome, Newborn / immunology, metabolism |
| Grant Support | |
ID/Acronym/Agency:
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HL56590/HL/NHLBI NIH HHS; HL60231/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Cytokines; 0/Interleukin-1 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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