Document Detail


Interleukin-1beta in the bronchoalveolar lavage fluid of premature neonates: a marker for maternal chorioamnionitis and predictor of adverse neonatal outcome.
MedLine Citation:
PMID:  14694976     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To determine whether the presence of the proinflammatory cytokine interleukin (IL)-1beta in the lungs of preterm infants immediately after birth was associated with maternal inflammation and could predict adverse neonatal outcome. STUDY DESIGN: Prospective evaluation of serially obtained tracheal aspirates for the presence of IL-1beta in 25 preterm infants (birth weight 595-1700 g; gestational age 24-32 weeks) with respiratory distress syndrome. The initial tracheal aspirate was obtained within 1 h after delivery. RESULTS: An initial tracheal aspirate positive for IL-1beta had a highly significant correlation with documented maternal chorioamnionitis for the given patient. In addition, the presence of IL-1beta correlated significantly with elevated total cell count (2.62 vs. 0.96 x 10(6)/ml, p = 0.0097), granulocyte count (2.12 vs. 0.22 x 10(6)/ml, p = 0.001), macrophage count (0.28 vs. 0.01 x 10(6)/ml, p = 0.02) and the presence of proinflammatory cytokines IL-6, IL-8 and tumor necrosis factor (TNF)-alpha. Preterm neonates positive for IL-1beta in their initial sample were on prolonged assisted ventilation (38 vs. 16 days, p = 0.013) and oxygen supplementation (62 vs. 40.5 days, p = 0.0462) and required prolonged hospitalization (69 vs. 46 days, p = 0.0165). CONCLUSIONS: The concentration of IL-1beta in the initial tracheal aspirate obtained from the lungs of preterm infants within the first hour of life may serve as a marker of antenatal/perinatal inflammation, probably due to maternal chorioamnionitis, and could predict an adverse clinical course and short-term outcome.
Authors:
R G Cayabyab; C A Jones; K Y C Kwong; C Hendershott; C Lecart; P Minoo; R Ramanathan
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians     Volume:  14     ISSN:  1476-7058     ISO Abbreviation:  J. Matern. Fetal. Neonatal. Med.     Publication Date:  2003 Sep 
Date Detail:
Created Date:  2003-12-25     Completed Date:  2004-03-04     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  101136916     Medline TA:  J Matern Fetal Neonatal Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  205-11     Citation Subset:  IM    
Affiliation:
Division of Neonatology and Allergy/Immunology, Department of Pediatrics, Women's and Children's Hospital, LAC and USC Medical Center, University of Southern California School of Medicine, Los Angeles, California 90033, USA.
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MeSH Terms
Descriptor/Qualifier:
Biological Markers / analysis
Bronchoalveolar Lavage Fluid / cytology*
Cesarean Section / utilization
Chorioamnionitis / immunology*
Cytokines / metabolism
Female
Humans
Infant, Newborn
Infant, Premature / metabolism*
Interleukin-1 / metabolism*
Intubation, Intratracheal
Length of Stay / statistics & numerical data
Male
Outcome Assessment (Health Care)
Oxygen Inhalation Therapy
Pregnancy
Prospective Studies
Respiration, Artificial
Respiratory Distress Syndrome, Newborn / immunology,  metabolism
Grant Support
ID/Acronym/Agency:
HL56590/HL/NHLBI NIH HHS; HL60231/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Biological Markers; 0/Cytokines; 0/Interleukin-1

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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