Document Detail

Interleukin-1beta depresses hypoxic gasping and autoresuscitation in neonatal DBA/1lacJ mice.
MedLine Citation:
PMID:  15766902     Owner:  NLM     Status:  MEDLINE    
The pro-inflammatory cytokine interleukin-1beta (IL-1beta) has been proposed to act as an important mediator between infection and apnea in neonates. In this study, respiration and the ability to survive anoxic challenge were investigated between 70 and 95 min after intraperitoneal injection of IL-1beta (10 microg/kg) or NaCl in 9-day-old DBA/1lacJ mice. Using flow plethysmography, we show that mice given IL-1beta exhibited a decreased tidal volume (V(T)) and minute ventilation (V(E)) during normoxia compared to control animals. Hyperoxic challenge revealed functioning peripheral chemoreceptors in all animals, suggesting a central mechanism underlying the ventilatory effects of IL-1beta. In response to anoxia (100% N2), all animals irrespective of treatment displayed a biphasic ventilatory pattern. Mice given IL-1beta exhibited fewer gasps and were unable to sustain gasping efforts for as long as control animals. Additionally, they were less able to autoresuscitate and survive following severe hypoxic apnea. These findings indicate that infection may adversely affect central respiratory control in newborn mice via interleukin-1beta.
Annika Olsson Hofstetter; Eric Herlenius
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Respiratory physiology & neurobiology     Volume:  146     ISSN:  1569-9048     ISO Abbreviation:  Respir Physiol Neurobiol     Publication Date:  2005 Apr 
Date Detail:
Created Date:  2005-03-15     Completed Date:  2005-05-20     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  101140022     Medline TA:  Respir Physiol Neurobiol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  135-46     Citation Subset:  IM    
Neonatal Research Unit, Q2:07, Department of Woman and Child Health, Astrid Lindgren Children's Hospital, Karolinska Institutet, S-171 76 Stockholm, Sweden.
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MeSH Terms
Animals, Newborn
Anoxia / physiopathology*
Hypercapnia / physiopathology
Interleukin-1 / pharmacology*
Mice, Inbred DBA
Plethysmography / methods
Pulmonary Ventilation
Respiration / drug effects*
Tidal Volume / drug effects
Time Factors
Reg. No./Substance:

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