| Interleukin-1beta (IL-1beta) processing pathway. | |
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MedLine Citation:
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PMID: 20086236 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The innate immune system senses molecular patterns from invading microorganisms. Once activated, it orchestrates the inflammatory response by secreting proinflammatory cytokines, such as interleukin-1 (IL-1)-type cytokines, in particular IL-1beta. IL-1 mediates the expression of a vast array of genes involved in secondary inflammation. IL-1-responsive genes coordinate all aspects of local inflammation and also attract and activate cells of the adaptive immune system at sites of infection. Moreover, the innate immune system can also sense a wide range of nonmicrobial molecular patterns that represent danger or damage signals. These signals activate the NALP3-inflammasome pathway, which plays a central role in acute and chronic sterile inflammation. Here, we describe the essential components of the NALP3-inflammasome that control processing and release of IL-1beta. |
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Authors:
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Axel Weber; Peter Wasiliew; Michael Kracht |
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Publication Detail:
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Type: Journal Article; Review Date: 2010-01-19 |
Journal Detail:
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Title: Science signaling Volume: 3 ISSN: 1937-9145 ISO Abbreviation: Sci Signal Publication Date: 2010 |
Date Detail:
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Created Date: 2010-01-20 Completed Date: 2010-05-13 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101465400 Medline TA: Sci Signal Country: United States |
Other Details:
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Languages: eng Pagination: cm2 Citation Subset: IM |
Affiliation:
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Rudolf-Buchheim-Institute of Pharmacology, Justus-Liebig-University Giessen, 35392 Giessen, Germany. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Carrier Proteins / metabolism Humans Immunity, Innate Inflammation / metabolism Interleukin-1beta / immunology, metabolism* Signal Transduction / immunology* |
| Chemical | |
Reg. No./Substance:
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0/Carrier Proteins; 0/Interleukin-1beta; 0/NLRP3 protein, human |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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