| Interleukin-19: multiple roles in immune regulation and disease. | |
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MedLine Citation:
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PMID: 20889366 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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First reported in 1999, IL-19 remains a mystery in many ways. Despite appearing in many genome scans and candidate gene studies, and having been searched for specifically as part of the IL-10 family, its function is still to be defined. Nonetheless, a pattern of Th2 promotion is coalescing from this nebulous body of work, supported by increasing evidence for a role in asthma. Similarly, a clear but less intuitive role as a subtle immunomodulator is emerging in psoriasis and chronic inflammatory disorders in general. Indeed, several human diseases and their animal models have highlighted a role for IL-19. Key questions remain, relating to the nature of its receptor, its function (if any) on leukocytes and how its effects are distinguished by the cell from those of IL-20 and IL-24. In this review, I shall attempt to bring together a summary of the known work - disparate as it may be - as well as presenting a picture of these two important clinical disorders and the potential involvement of this somewhat enigmatic cytokine. |
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Authors:
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Grant Gallagher |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Cytokine & growth factor reviews Volume: 21 ISSN: 1879-0305 ISO Abbreviation: Cytokine Growth Factor Rev. Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-12-06 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9612306 Medline TA: Cytokine Growth Factor Rev Country: England |
Other Details:
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Languages: eng Pagination: 345-52 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Elsevier Ltd. All rights reserved. |
Affiliation:
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Genetic Immunology Laboratory, HUMIGEN, The Institute for Genetic Immunology, 2439 Kuser Road, Hamilton, NJ 08690-3303, USA. G.Gallagher@humigen.org |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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