Document Detail

Interleukin-18: a strong predictor of the extent of coronary artery disease in patients with unstable angina.
MedLine Citation:
PMID:  18043993     Owner:  NLM     Status:  MEDLINE    
The aim of this study was to confirm that plasma interleukin (IL)-18 level is associated with the extent of coronary artery disease in unstable angina patients. Previous studies have shown that patients with unstable angina have significantly higher plasma IL-18 levels than healthy volunteers. However, the association between IL-18 and the extent of coronary artery atherosclerosis in patients with unstable angina remains unclear. Plasma concentrations of IL-18 and high-sensitivity C-reactive protein (hs-CRP) were measured in 166 consecutive patients admitted for coronary arteriography. One hundred and eighteen patients with unstable angina had coronary artery disease (coronary artery disease group; severity score: 2.32 +/- 1.47; Gensini score: 31.3 +/- 25.9), and 48 patients with coronary risk factors and without coronary artery lesions served as the risk control group. Plasma levels of IL-18 were higher in the coronary artery disease group than in the risk control group (P = 0.062). Additionally, plasma levels of IL-18 were significantly higher in 77 coronary artery disease patients with severity score > or =2 than in the risk control group (242.3 +/- 110.6 vs 209.8 +/- 120.3 pg/ml, P = 0.016). By univariate analysis, log-transformed plasma IL-18 concentration was positively correlated with coronary artery disease severity score (r = 0.244, P = 0.009). By multiple regression analyses, the association between coronary artery disease severity score and IL-18 remained significant (beta = 0.733, P = 0.017) when controlling for age, diabetes mellitus and left ventricular ejection fraction. Additionally, coronary artery disease severity score was greater in the highest tertile (>246 pg/ml) of plasma IL-18 levels than in the middle (176-246 pg/ml) and the lowest (<176 pg/ml) tertiles (2.79 +/- 1.52 vs 2.05 +/- 1.08 vs 2.13 +/- 1.66, P = 0.028). Of note, plasma hs-CRP level had no significant correlation with coronary artery severity. Plasma IL-18 level is associated with the extent of coronary artery disease in unstable angina patients, suggesting the link between IL-18 and coronary artery atherosclerosis in these patients.
Mien-Cheng Chen; Chien-Jen Chen; Cheng-Hsu Yang; Chiung-Jen Wu; Chih-Yuan Fang; Yuan-Kai Hsieh; Hsueh-Wen Chang
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-11-26
Journal Detail:
Title:  Heart and vessels     Volume:  22     ISSN:  0910-8327     ISO Abbreviation:  Heart Vessels     Publication Date:  2007 Nov 
Date Detail:
Created Date:  2007-11-28     Completed Date:  2008-06-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8511258     Medline TA:  Heart Vessels     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  371-5     Citation Subset:  IM    
Division of Cardiology, Department of Internal Medicine, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Chang Gung University College of Medicine, Niao Sung Hsiang, Kaohsiung Hsien, Taiwan.
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MeSH Terms
Angina, Unstable / blood*,  etiology
C-Reactive Protein / analysis*
Coronary Artery Disease / blood*,  complications
Interleukin-18 / blood*
Middle Aged
Predictive Value of Tests
Severity of Illness Index
Reg. No./Substance:
0/Interleukin-18; 9007-41-4/C-Reactive Protein

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