Document Detail


Interleukin 18 participates in the early inflammatory response and bacterial clearance during pneumonia caused by nontypeable Haemophilus influenzae.
MedLine Citation:
PMID:  17664259     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Nontypeable Haemophilus influenzae (NTHi) is a common gram-negative respiratory pathogen. To determine the role of the proinflammatory cytokine interleukin 18 (IL-18) during NTHi pneumonia, normal wild-type (WT) and IL-18 knockout (KO) mice were intranasally infected with NTHi. IL-18 KO mice displayed a delayed clearance of NTHi from the respiratory tract, resulting in >20-fold higher bacterial loads in their lungs at 24 h after infection, preceded by a strongly attenuated pulmonary innate immune response as determined by cytokine and chemokine induction and histopathology. These data identify IL-18 as part of an adequate innate immune response during NTHi pneumonia.
Authors:
Catharina W Wieland; Sandrine Florquin; Tom van der Poll
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Publication Detail:
Type:  Journal Article     Date:  2007-07-30
Journal Detail:
Title:  Infection and immunity     Volume:  75     ISSN:  0019-9567     ISO Abbreviation:  Infect. Immun.     Publication Date:  2007 Oct 
Date Detail:
Created Date:  2007-09-20     Completed Date:  2007-10-31     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0246127     Medline TA:  Infect Immun     Country:  United States    
Other Details:
Languages:  eng     Pagination:  5068-72     Citation Subset:  IM    
Affiliation:
Center of Infection and Immunity, G2-132, Academic Medical Center, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands. c.wieland@amc.uva.nl
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MeSH Terms
Descriptor/Qualifier:
Animals
Chemokines / biosynthesis
Colony Count, Microbial
Cytokines / biosynthesis
Haemophilus Infections / immunology*
Haemophilus influenzae / immunology*
Interleukin-18 / immunology*
Lung / microbiology,  pathology
Mice
Mice, Inbred C57BL
Mice, Knockout
Models, Biological
Pneumonia, Bacterial / immunology*
Chemical
Reg. No./Substance:
0/Chemokines; 0/Cytokines; 0/Interleukin-18
Comments/Corrections

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