Document Detail

Interleukin-18 in patients with congestive heart failure: induction of atrial natriuretic peptide gene expression.
MedLine Citation:
PMID:  11758978     Owner:  NLM     Status:  MEDLINE    
Activated inflammatory responses appear to play a role in the development of congestive heart failure (CHF). We investigated interleukin-18 (IL-18), which is a cytokine synthesized by activated macrophage, changes in patients with CHF. We evaluated 11 Japanese patients with angina pectoris (n=4) or CHF (n=7). Blood was sampled immediately after admission and at 1, 2, 3, 6, and 9 hours after admission and then every 12 hours until 5 days after admission. Plasma IL-18 concentrations were measured by an enzyme-linked immunosorbent assay. Expression of atrial natriuretic peptide (ANP) mRNA and protein synthesis was examined in cardiac myocyte by stimulation of IL-18. Plasma IL-18 concentration was significantly higher in patients with CHF than in 15 healthy volunteers (51+/-21 pg/mL, and 28+11 pg/mL, respectively, P<0.05). Increased expression of ANP mRNA was demonstrated in IL-18 treated myocytes. Protein synthesis in myocytes was increased by IL-18 in a dose-dependent manner. Increased secretion of IL-18 is induced in patients with CHF and correlates with the severity of myocardial damage and dysfunction.
Y Seta; T Kanda; T Tanaka; M Arai; K Sekiguchi; T Yokoyama; M Kurimoto; J Tamura; M Kurabayashi
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Research communications in molecular pathology and pharmacology     Volume:  108     ISSN:  1078-0297     ISO Abbreviation:  Res. Commun. Mol. Pathol. Pharmacol.     Publication Date:    2000 Jul-Aug
Date Detail:
Created Date:  2001-12-07     Completed Date:  2002-01-07     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9437512     Medline TA:  Res Commun Mol Pathol Pharmacol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  87-95     Citation Subset:  IM    
Second Department of Internal Medicine, Gunma University School of Medicine, Maebashi, Japan.
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MeSH Terms
Atrial Natriuretic Factor / biosynthesis*,  genetics
Biological Markers
Cardiomegaly / blood
Cells, Cultured
Gene Expression Regulation / physiology*
Heart Failure / blood*
Interleukin-18 / blood*
Middle Aged
Muscle Proteins / biosynthesis
Myocardium / metabolism
RNA, Messenger / biosynthesis
Reg. No./Substance:
0/Biological Markers; 0/Interleukin-18; 0/Muscle Proteins; 0/RNA, Messenger; 85637-73-6/Atrial Natriuretic Factor

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