| Interleukin-18 contributes more closely to the progression of diabetic nephropathy than other diabetic complications. | |
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MedLine Citation:
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PMID: 20186552 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Diabetic complication is comprised of a wide variety of pathophysiological factors involving proinflammatory cytokines, adipokines, and oxidative stress, among others. Each of these complications differs in their incidence and the stage of their occurrence. We examined cytokines and stress markers in 48 patients with type 2 diabetes mellitus and compared the difference of their contribution to pathogenesis between nephropathy and other diabetic complications. Hemoglobin A1c correlated with the level of low-density lipoprotein-cholesterol, and significantly elevated in the severe macroangiopathy group. Cystatin C increased in the severe microangiopathy groups but did not increase in the macroangiopathy group. The levels of interleukin 18 (IL-18), high-sensitive CRP (H-CRP), liver-type fatty acid binding protein, and 8-hydroxy-2-deoxyguanosine increased in the severe microangiopathy group. These data suggest the participation of proinflammatory signaling and oxidative stress in the progression of microangiopathy. In particular, IL-18 and H-CRP were significantly elevated only in the severe nephropathy group but did not significantly elevate in other complications. These data suggest another effect of IL-18 on glomerulus in addition to its proinflammatory effect. In conclusion, we propose that IL18 has a specific role that contributes more closely to the progression of diabetic nephropathy than other diabetic complications. |
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Authors:
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Takayuki Fujita; Norikazu Ogihara; Yumi Kamura; Atsushi Satomura; Yoshinobu Fuke; Chie Shimizu; Yuki Wada; Koichi Matsumoto |
Publication Detail:
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Type: Journal Article Date: 2010-02-26 |
Journal Detail:
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Title: Acta diabetologica Volume: 49 ISSN: 1432-5233 ISO Abbreviation: Acta Diabetol Publication Date: 2012 Apr |
Date Detail:
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Created Date: 2012-03-28 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9200299 Medline TA: Acta Diabetol Country: Germany |
Other Details:
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Languages: eng Pagination: 111-7 Citation Subset: IM |
Affiliation:
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Department of Nephrology, Hypertension and Endocrinology, Nihon University School of Medicine, 30-1 Oyaguchi-Kamimachi, Itabashiku, Tokyo, 173-8610, Japan, tfujita@med.nihon-u.ac.jp. |
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