Document Detail


Interleukin 17 production among patients with American cutaneous leishmaniasis.
MedLine Citation:
PMID:  19476435     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Interleukin 17 (IL-17) plays a critical role in inflammation and autoimmunity. Very little is known about IL-17 in protozoa infection. Here, we show that lymphocytes obtained from patients with mucosal leishmaniasis and cutaneous leishmaniasis produce higher levels of IL-17 than do lymphocytes obtained from uninfected control subjects (P<.01). There was a tendency for tissue obtained from patients with mucosal leishmaniasis to contain a higher number of cells expressing IL-17, compared with tissue obtained from patients with cutaneous leishmaniasis, and there was a direct correlation between the number of cells expressing IL-17 and the presence of cellular inflammation at the lesion site (r2 = 0.86; P<.001) These data support the role of IL-17 in the pathogenesis of the inflammatory reaction in leishmaniasis.
Authors:
Olívia Bacellar; Daniela Faria; Márcia Nascimento; Thiago M Cardoso; Kenneth J Gollob; Walderez O Dutra; Phillip Scott; Edgar M Carvalho
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of infectious diseases     Volume:  200     ISSN:  0022-1899     ISO Abbreviation:  J. Infect. Dis.     Publication Date:  2009 Jul 
Date Detail:
Created Date:  2009-07-09     Completed Date:  2009-09-14     Revised Date:  2013-07-19    
Medline Journal Info:
Nlm Unique ID:  0413675     Medline TA:  J Infect Dis     Country:  United States    
Other Details:
Languages:  eng     Pagination:  75-8     Citation Subset:  AIM; IM    
Affiliation:
Serviço de Imunologia, Hospital Universitário Prof. Edgard Santos, Universidade Federal da Bahia, Salvador-Bahia, Brazil.
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MeSH Terms
Descriptor/Qualifier:
Autoimmunity
Humans
Inflammation / immunology
Interleukin-17 / genetics*
Leishmaniasis, Mucocutaneous / genetics,  immunology*
Lymphocyte Activation / genetics,  immunology
Lymphocytes / immunology*
Reference Values
Th1 Cells / immunology
Grant Support
ID/Acronym/Agency:
AI-30639/AI/NIAID NIH HHS; D43 TW007127/TW/FIC NIH HHS; D43 TW007127/TW/FIC NIH HHS; D43 TW007127-05/TW/FIC NIH HHS; P50 AI030639/AI/NIAID NIH HHS; P50 AI030639-16/AI/NIAID NIH HHS
Chemical
Reg. No./Substance:
0/Interleukin-17
Comments/Corrections

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