| Interleukin 17 production among patients with American cutaneous leishmaniasis. | |
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MedLine Citation:
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PMID: 19476435 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Interleukin 17 (IL-17) plays a critical role in inflammation and autoimmunity. Very little is known about IL-17 in protozoa infection. Here, we show that lymphocytes obtained from patients with mucosal leishmaniasis and cutaneous leishmaniasis produce higher levels of IL-17 than do lymphocytes obtained from uninfected control subjects (P<.01). There was a tendency for tissue obtained from patients with mucosal leishmaniasis to contain a higher number of cells expressing IL-17, compared with tissue obtained from patients with cutaneous leishmaniasis, and there was a direct correlation between the number of cells expressing IL-17 and the presence of cellular inflammation at the lesion site (r2 = 0.86; P<.001) These data support the role of IL-17 in the pathogenesis of the inflammatory reaction in leishmaniasis. |
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Authors:
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Olívia Bacellar; Daniela Faria; Márcia Nascimento; Thiago M Cardoso; Kenneth J Gollob; Walderez O Dutra; Phillip Scott; Edgar M Carvalho |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The Journal of infectious diseases Volume: 200 ISSN: 0022-1899 ISO Abbreviation: J. Infect. Dis. Publication Date: 2009 Jul |
Date Detail:
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Created Date: 2009-07-09 Completed Date: 2009-09-14 Revised Date: 2010-09-27 |
Medline Journal Info:
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Nlm Unique ID: 0413675 Medline TA: J Infect Dis Country: United States |
Other Details:
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Languages: eng Pagination: 75-8 Citation Subset: AIM; IM |
Affiliation:
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Serviço de Imunologia, Hospital Universitário Prof. Edgard Santos, Universidade Federal da Bahia, Salvador-Bahia, Brazil. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Autoimmunity Humans Inflammation / immunology Interleukin-17 / genetics* Leishmaniasis, Mucocutaneous / genetics, immunology* Lymphocyte Activation / genetics, immunology Lymphocytes / immunology* Reference Values Th1 Cells / immunology |
| Grant Support | |
ID/Acronym/Agency:
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AI-30639/AI/NIAID NIH HHS; D43 TW007127/TW/FIC NIH HHS; D43 TW007127-05/TW/FIC NIH HHS; P50 AI030639-16/AI/NIAID NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Interleukin-17 |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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