Document Detail


Interleukin-17 and kidney allograft outcome.
MedLine Citation:
PMID:  19545679     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Acute rejection episodes (ARE) are important complications that involve the interplay between mechanisms that maintain graft tolerance and promote rejection. The proinflammatory cytokine interleukin-17 (IL-17) has been implicated in many conditions in humans and mice. In kidney transplant patients, the evaluation IL-17 levels has been performed in only a few patients. We performed a cross-sectional study correlating quantitative IL-17 levels and clinical outcomes. PATIENTS AND METHODS: We studied 19 specimens from biopsies performed in patients (n = 19) who received isolated kidney grafts. ARE signs were present in 9 (47%) patients who provide specimens; whereas, 10 (53%) others showed no signs of rejection. Eighteen healthy control sample IL-17 underwent measurement, all of which were performed by an enzyme-linked immunosorbent assay method. We assessed other factors, such as the recipients demographic data, cold ischemia time, HLA mismatches, time elapsed from transplantation to the biopsy, posttransplantation status, antibody panel, donor type, and immunosuppressive treatment. RESULTS: IL-17 levels were clearly increased among samples derived from patients with ongoing rejection (125.7 +/- 27.06 pg/mL) in contrast, to the nonrejection group, (30 +/- 13.32 pg/mL) (P < .05). Healthy controls showed no detectable IL-17 levels. CONCLUSIONS: These findings suggested that IL-17 was important in the pathophysiology of acute kidney rejection.
Authors:
J C O Crispim; R Grespan; G Martelli-Palomino; D M Rassi; R S Costa; L T Saber; F Q Cunha; E A Donadi
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Transplantation proceedings     Volume:  41     ISSN:  1873-2623     ISO Abbreviation:  Transplant. Proc.     Publication Date:  2009 Jun 
Date Detail:
Created Date:  2009-06-23     Completed Date:  2009-09-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0243532     Medline TA:  Transplant Proc     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1562-4     Citation Subset:  IM    
Affiliation:
Department of Biochemistry and Immunology, School of Medicine of Ribeirão Preto, University of São Paulo, (FMRP-USP), São Paulo, Brazil. janacrispim@usp.br
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MeSH Terms
Descriptor/Qualifier:
Adult
Animals
Biological Markers / blood*
Biopsy
Female
Graft Rejection / blood*,  immunology
Humans
Immunosuppressive Agents / therapeutic use
Interleukin-17 / blood*
Male
Mice
Middle Aged
Reference Values
Chemical
Reg. No./Substance:
0/Biological Markers; 0/Immunosuppressive Agents; 0/Interleukin-17

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