Document Detail


Interleukin-17 and interleukin-23: importance in the pathogenesis of lung impairment in patients with systemic sclerosis.
MedLine Citation:
PMID:  24467649     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
AIM: T cell abnormalities with a focus on Th17 cells have been associated with the pathogenesis of systemic sclerosis (SSc) and interstitial lung disease (ILD). The aim of this study was to evaluate serum levels of interleukin (IL)-17, IL-21 and IL-23 in SSc patients and to assess their relationship with ILD-SSc.
METHODS: Thirty-eight patients with SSc and 39 healthy controls were recruited. Serum IL-17, IL-21 and IL-23 levels were examined using enzyme-linked immunosorbent assay (ELISA). Lung involvement of SSc patients was assessed functionally (diffusing capacity of the lung for carbon monoxide [DLCO], body plethysmography) and radiologically (using average disease extent on high resolution computed tomography [HRCT] of the lungs according to the percentage of interstitial changes and quantified with a 30-point Warrick score) in 29 SSc patients.
RESULTS: Serum IL-17 and IL-23 levels were significantly decreased and IL-21 levels were elevated in SSc patients when compared with controls (P < 0.001, P < 0.001, P < 0.01, respectively). The level of IL-17 was negatively associated with disease duration (P = 0.01) and positively with HRCT Warrick score (P = 0.03). IL-23 concentration negatively correlated with DLCO (P = 0.04), total lung capacity (TLC) (P = 0.01) and the 6-min walk test distance (P = 0.03). No associations were found between the cytokine levels and the average extent of the disease on HRCT.
CONCLUSION: While the relationship between Th17-associated cytokines and ILD-SSc needs to be verified in a larger cohort of patients, the changes in concentrations of IL-17, IL-21 and IL-23 support the hypothesis that these cytokines may play a role in the pathogenesis of SSc.
Authors:
Anna Olewicz-Gawlik; Aleksandra Danczak-Pazdrowska; Barbara Kuznar-Kaminska; Justyna Gornowicz-Porowska; Katarzyna Katulska; Dorota Trzybulska; Halina Batura-Gabryel; Wojciech Silny; Dariusz Poplawski; Pawel Hrycaj
Related Documents :
24330309 - The degree of whey hydrolysis does not uniformly affect in vitro basophil and t cell re...
24467649 - Interleukin-17 and interleukin-23: importance in the pathogenesis of lung impairment in...
22938819 - Epilepsy, poverty and early under-nutrition in rural ethiopia.
23993429 - Clinical and metabolic findings in patients with methionine adenosyltransferase i/iii d...
23001639 - Peri-aortic fat tissue and malnutrition-inflammation-atherosclerosis/calcification synd...
24914029 - Secondary medical prevention and clinical outcome in coronary artery disease patients w...
24368199 - Time-lag between symptom onset and laboratory findings in patients with subacute thyroi...
19475659 - Decreased ventilatory response to hypercapnia in dementia with lewy bodies.
20299629 - Swallowing dysfunction in nonneurologic critically ill patients who require percutaneou...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-1-28
Journal Detail:
Title:  International journal of rheumatic diseases     Volume:  -     ISSN:  1756-185X     ISO Abbreviation:  Int J Rheum Dis     Publication Date:  2014 Jan 
Date Detail:
Created Date:  2014-1-28     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101474930     Medline TA:  Int J Rheum Dis     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2014 Asia Pacific League of Associations for Rheumatology and Wiley Publishing Asia Pty Ltd.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  High invasiveness of pneumococcal serotypes included in the new generation of conjugate vaccines.
Next Document:  An immunomodulatory role for the Mycobacterium tuberculosis RD1 locus proteins PE35 (Rv3872) and PPE...