Document Detail


Interleukin-17 and interleukin-23 are elevated in serum and cerebrospinal fluid of patients with ALS: a reflection of Th17 cells activation?
MedLine Citation:
PMID:  20219021     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: There is evidence that immunological factors may involved in pathogenetic mechanisms of amyotrophic lateral sclerosis (ALS). Th17 cells are characterized by predominant production of IL-17 and are suggested to be crucial in destructive autoimmunity. Interleukin-23 (IL-23) appears to play a supporting role in the continued stimulation and survival of Th17.
PATIENTS AND METHODS: We measured by enzyme-like immunosorbent assay (ELISA) serum and cerebrospinal fluid (CSF) levels of IL-17 and IL-23 in 22 patients with ALS and 19 patients with other non-inflammatory neurological disorders (NIND) studied as a control group. IL-17 and IL-23 serum and CSF levels were also correlated with duration of the disease, the disability level and the clinical subtype of the disease onset in patients with ALS.
RESULTS: IL-17 and IL-23 serum levels were higher in patients with ALS as compared with patients with NIND (P = 0.015 and P = 0.002 respectively). IL-17 and IL-23 CSF levels were also increased in patients with ALS (P = 0.0006 and P = 0.000001 respectively). IL-17 and IL-23 levels were not correlated with disease duration, disability scale or clinical subtype of the disease onset in ALS patients.
CONCLUSIONS: Our findings suggest that these molecules may be involved in the pathogenetic mechanisms acting as potential markers of Th17 cells activation in ALS.
Authors:
M Rentzos; A Rombos; C Nikolaou; M Zoga; V Zouvelou; A Dimitrakopoulos; T Alexakis; A Tsoutsou; A Samakovli; M Michalopoulou; J Evdokimidis
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta neurologica Scandinavica     Volume:  122     ISSN:  1600-0404     ISO Abbreviation:  Acta Neurol. Scand.     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2010-10-25     Completed Date:  2011-02-09     Revised Date:  2011-12-29    
Medline Journal Info:
Nlm Unique ID:  0370336     Medline TA:  Acta Neurol Scand     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  425-9     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 The Authors. Journal compilation © 2010 Blackwell Munksgaard.
Affiliation:
Department of Neurology, Aeginition Hospital, Athens National University, School of Medicine, Athens, Greece. mrentzos@med.uoa.gr
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Amyotrophic Lateral Sclerosis / blood*,  cerebrospinal fluid*,  immunology
Enzyme-Linked Immunosorbent Assay / methods
Female
Humans
Interleukin-17 / blood*,  cerebrospinal fluid*
Interleukin-23 / blood*,  cerebrospinal fluid*
Male
Middle Aged
Statistics, Nonparametric
Chemical
Reg. No./Substance:
0/Interleukin-17; 0/Interleukin-23
Comments/Corrections
Comment In:
Acta Neurol Scand. 2011 Oct;124(4):293; author reply 294   [PMID:  21943036 ]

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