| Interleukin-17 and interleukin-23 are elevated in serum and cerebrospinal fluid of patients with ALS: a reflection of Th17 cells activation? | |
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MedLine Citation:
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PMID: 20219021 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: There is evidence that immunological factors may involved in pathogenetic mechanisms of amyotrophic lateral sclerosis (ALS). Th17 cells are characterized by predominant production of IL-17 and are suggested to be crucial in destructive autoimmunity. Interleukin-23 (IL-23) appears to play a supporting role in the continued stimulation and survival of Th17. PATIENTS AND METHODS: We measured by enzyme-like immunosorbent assay (ELISA) serum and cerebrospinal fluid (CSF) levels of IL-17 and IL-23 in 22 patients with ALS and 19 patients with other non-inflammatory neurological disorders (NIND) studied as a control group. IL-17 and IL-23 serum and CSF levels were also correlated with duration of the disease, the disability level and the clinical subtype of the disease onset in patients with ALS. RESULTS: IL-17 and IL-23 serum levels were higher in patients with ALS as compared with patients with NIND (P = 0.015 and P = 0.002 respectively). IL-17 and IL-23 CSF levels were also increased in patients with ALS (P = 0.0006 and P = 0.000001 respectively). IL-17 and IL-23 levels were not correlated with disease duration, disability scale or clinical subtype of the disease onset in ALS patients. CONCLUSIONS: Our findings suggest that these molecules may be involved in the pathogenetic mechanisms acting as potential markers of Th17 cells activation in ALS. |
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Authors:
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M Rentzos; A Rombos; C Nikolaou; M Zoga; V Zouvelou; A Dimitrakopoulos; T Alexakis; A Tsoutsou; A Samakovli; M Michalopoulou; J Evdokimidis |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Acta neurologica Scandinavica Volume: 122 ISSN: 1600-0404 ISO Abbreviation: Acta Neurol. Scand. Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2010-10-25 Completed Date: 2011-02-09 Revised Date: 2011-12-29 |
Medline Journal Info:
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Nlm Unique ID: 0370336 Medline TA: Acta Neurol Scand Country: Denmark |
Other Details:
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Languages: eng Pagination: 425-9 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 The Authors. Journal compilation © 2010 Blackwell Munksgaard. |
Affiliation:
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Department of Neurology, Aeginition Hospital, Athens National University, School of Medicine, Athens, Greece. mrentzos@med.uoa.gr |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Amyotrophic Lateral Sclerosis / blood*, cerebrospinal fluid*, immunology Enzyme-Linked Immunosorbent Assay / methods Female Humans Interleukin-17 / blood*, cerebrospinal fluid* Interleukin-23 / blood*, cerebrospinal fluid* Male Middle Aged Statistics, Nonparametric |
| Chemical | |
Reg. No./Substance:
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0/Interleukin-17; 0/Interleukin-23 |
| Comments/Corrections | |
Comment In:
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Acta Neurol Scand. 2011 Oct;124(4):293; author reply 294
[PMID:
21943036
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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