| Interleukin-17: friend or foe in atherosclerosis? | |
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MedLine Citation:
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PMID: 20683328 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE OF REVIEW: To summarize the current knowledge on the origin and physiological function of T helper 17 (Th17) and discuss the contrasting results pertaining to the role of Th17 and interleukin-17 (IL-17) in atherosclerosis. RECENT FINDINGS: Atherosclerosis is a chronic inflammatory arterial disease driven by both innate and adaptive immune responses to modified lipoproteins. Although initial studies have focused on the role of Th1 and Th2 responses in atherosclerosis, more recent findings identified atheroprotective roles for several subsets of regulatory T cells. Th17 represents a new T-cell lineage with important roles in the clearance of pathogenic bacteria and fungi. The increase of Th17 and IL-17 has been recently linked to the pathogenesis of several autoimmune diseases. However, its role in chronic inflammatory diseases such as atherosclerosis remains poorly understood. The few studies available on this topic have generated contrasting results, which could be attributed to different approaches used on various mouse models. SUMMARY: IL-17 seems to have a modulatory role in atherosclerosis. Future studies are needed to better determine the molecular mechanisms involved in this regulation and examine whether targeting IL-17 pathway will be useful to treat cardiovascular diseases. |
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Authors:
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Soraya Taleb; Alain Tedgui; Ziad Mallat |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Current opinion in lipidology Volume: 21 ISSN: 1473-6535 ISO Abbreviation: Curr. Opin. Lipidol. Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-09-09 Completed Date: 2010-12-17 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9010000 Medline TA: Curr Opin Lipidol Country: England |
Other Details:
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Languages: eng Pagination: 404-8 Citation Subset: IM |
Affiliation:
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Institut National de la Sante et de la Recherche Medicale (Inserm), Unit 970 and Paris-Descartes University, Paris, France. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Atherosclerosis / immunology, metabolism* Autoimmune Diseases / immunology, metabolism Humans Interleukin-17 / metabolism* T-Lymphocytes, Helper-Inducer / immunology, metabolism |
| Chemical | |
Reg. No./Substance:
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0/Interleukin-17 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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