| Interleukin 17 and RANTES levels in induced sputum of patients with allergic rhinitis after a single nasal allergen challenge. | |
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MedLine Citation:
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PMID: 19927541 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Interleukin 17 (IL-17) is produced by T(H)17 cells and was recently implicated in the development of the T(H)2 cell response. RANTES (regulated on activation of normal T cells expressed and secreted), among other chemokines, plays a crucial role in chemotaxis of eosinophils into airway mucosa. According to the "united airway" hypothesis, markers of inflammation in allergic diseases are elevated in the upper and lower airways. OBJECTIVE: To assess the impact of a single nasal allergen challenge on IL-17 and RANTES levels in induced sputum of patients with allergic rhinitis (AR). METHODS: Eighteen patients with a history of AR due to grass pollen confirmed by positive skin prick test results and 10 control subjects entered the study. Initially, all the patients underwent sputum induction. A single nasal placebo challenge was performed 24 hours later, with repeated sputum induction 24 hours after challenge. After 4 weeks of washout, these procedures were repeated with allergen challenge. Differential cell counts in sputum were determined, and concentrations of IL-17 and RANTES were measured by means of enzyme-linked immunosorbent assay. RESULTS: Levels of IL-17 and RANTES significantly increased in sputum of patients with AR after allergen (but not placebo) challenge (P = .03 and P = .007, respectively). Postallergen levels of both cytokines in sputum were positively correlated (r = 0.570, P = .02). Allergen challenge led to increased total inflammatory cell (P = .005) and eosinophil (P = .03) counts in induced sputum of patients with AR. CONCLUSIONS: Nasal allergen challenge induces the enhanced secretion of IL-17 and RANTES in the lower airways of nonasthmatic patients with AR. |
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Authors:
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Aleksandra Semik-Orzech; Adam Barczyk; Ryszard Wiaderkiewicz; Wladyslaw Pierzchala |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology Volume: 103 ISSN: 1081-1206 ISO Abbreviation: Ann. Allergy Asthma Immunol. Publication Date: 2009 Nov |
Date Detail:
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Created Date: 2009-11-20 Completed Date: 2009-12-11 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9503580 Medline TA: Ann Allergy Asthma Immunol Country: United States |
Other Details:
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Languages: eng Pagination: 418-24 Citation Subset: IM |
Affiliation:
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Department of Pulmonology, Medical University of Silesia, Katowice, Poland. asemik@interia.pl |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Allergens / immunology* Chemokine CCL5 / analysis, biosynthesis* Eosinophils / immunology Female Humans Interleukin-17 / analysis, biosynthesis* Male Nasal Provocation Tests Rhinitis, Allergic, Perennial / immunology* Sputum / chemistry, immunology* |
| Chemical | |
Reg. No./Substance:
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0/Allergens; 0/Chemokine CCL5; 0/Interleukin-17 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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