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Interleukin-17 Mediated Inflammatory Responses Are Required for Ultraviolet Radiation Induced Immune Suppression;
MedLine Citation:
PMID:  25250896     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Ultraviolet radiation (UVR) induces immunosuppression and is a major factor for development of skin cancer. Numerous efforts have been made to determine mechanisms for UVR induced immunosuppression and to develop strategies for prevention and treatment of UVR induced cancers. In the current study, we use IL-17 receptor (IL-17R) deficient mice to examine whether IL-17 mediated responses have a role in UVB (290-320) induced immunosuppression of contact hypersensitivity responses. Results demonstrate that IL-17 mediated responses are required for UVB induced immunosuppression of contact hypersensitivity responses. The systemic immune suppression and development of regulatory T cells are inhibited in UVB treated IL-17R deficient mice compared to wild type animals. The deficiency in IL-17R inhibits the infiltration and development of a tolerogenic myeloid cell population in UVB treated skin, which expresses CD11b and Gr-1 and produces reactive oxygen species. We speculate that the development of the tolerogenic myeloid cells is dependent on IL-17 induced chemokines and inflammatory mediators in UVB treated skin. The inhibition of the tolerogenic myeloid cells may be attributed to the suppression of regulatory T cells in UVR treated IL-17R-/- mice. The findings may be exploited to new strategies for prevention and treatment of UVR induced skin diseases and cancers. This article is protected by copyright. All rights reserved.
Authors:
Hui Li; Ram Prasad; Santosh K Katiyar; Nabiha Yusuf; Craig A Elmets; Hui Xu
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-9-23
Journal Detail:
Title:  Photochemistry and photobiology     Volume:  -     ISSN:  1751-1097     ISO Abbreviation:  Photochem. Photobiol.     Publication Date:  2014 Sep 
Date Detail:
Created Date:  2014-9-24     Completed Date:  -     Revised Date:  2014-9-25    
Medline Journal Info:
Nlm Unique ID:  0376425     Medline TA:  Photochem Photobiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
This article is protected by copyright. All rights reserved.
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