| Interleukin-15 inhibits smooth muscle cell proliferation and hyaluronan production in rat ductus arteriosus. | |
| | |
MedLine Citation:
|
PMID: 17667861 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Neointimal cushion formation (NCF) is an important vascular remodeling for anatomical closure of the ductus arteriosus (DA). Inflammatory responses to vascular injury or atherosclerosis are known to be associated with the pathogenesis of NCF. We found that the expression of interleukin (IL)-15 mRNA was significantly higher in rat DA than in the aorta. IL-15 immunoreactivity was detected predominantly in the internal elastic laminae (IEL) and to a lesser extent in smooth muscle cells (SMCs) in rat DA. Prostaglandin E (PGE) increased the expression of IL-15 mRNA in cultured DA SMCs. IL-15 significantly attenuated the platelet-derived growth factor (PDGF)-BB-mediated SMC proliferation, but did not change SMC migration. IL-15 significantly attenuated PGE1-induced hyaluronic acid (HA) production in a dose-dependent manner, which is a potent stimulator of NCF. Accordingly, IL-15 might have an inhibitory effect on the physiologic vascular remodeling processes in closing the DA. |
| | |
Authors:
|
Shiho Iwasaki; Susumu Minamisawa; Utako Yokoyama; Toru Akaike; Hong Quan; Yoji Nagashima; Shigeru Nishimaki; Yoshihiro Ishikawa; Shumpei Yokota |
Publication Detail:
|
Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Pediatric research Volume: 62 ISSN: 0031-3998 ISO Abbreviation: Pediatr. Res. Publication Date: 2007 Oct |
Date Detail:
|
Created Date: 2007-10-24 Completed Date: 2007-11-13 Revised Date: 2009-11-19 |
Medline Journal Info:
|
Nlm Unique ID: 0100714 Medline TA: Pediatr Res Country: United States |
Other Details:
|
Languages: eng Pagination: 392-8 Citation Subset: IM |
Affiliation:
|
Department of Pediatrics, Yokohama City University, Yokohama 236-0004, Japan. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Alprostadil
/
metabolism Animals Aorta / embryology, metabolism* Cell Movement Cell Proliferation* Cells, Cultured Chemokine CX3CL1 Chemokines, CX3C / metabolism Dose-Response Relationship, Drug Ductus Arteriosus / embryology, metabolism* Feedback, Physiological Gene Expression Regulation, Developmental Hyaluronic Acid / metabolism* Interleukin-15 / genetics, metabolism*, pharmacology Membrane Proteins / metabolism Methyl Ethers / pharmacology Muscle, Smooth, Vascular / embryology, metabolism* Myocytes, Smooth Muscle / metabolism* Platelet-Derived Growth Factor / metabolism RNA, Messenger / metabolism Rats Rats, Wistar Receptors, Chemokine / metabolism Receptors, Interleukin-15 / metabolism Receptors, Prostaglandin E / metabolism |
| Chemical | |
Reg. No./Substance:
|
0/CX3CR1 protein, rat; 0/Chemokine CX3CL1; 0/Chemokines, CX3C; 0/Cx3cl1 protein, rat; 0/Interleukin-15; 0/Membrane Proteins; 0/Methyl Ethers; 0/ONO-AE1-329; 0/Platelet-Derived Growth Factor; 0/RNA, Messenger; 0/Receptors, Chemokine; 0/Receptors, Interleukin-15; 0/Receptors, Prostaglandin E; 0/platelet-derived growth factor BB; 0/prostaglandin E2 receptor, EP4 subtype; 745-65-3/Alprostadil; 9004-61-9/Hyaluronic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Toll-like receptor 2 polymorphism is associated with preterm birth.
Next Document: Fatal infantile cardiac glycogenosis with phosphorylase kinase deficiency and a mutation in the gamm...