| Interleukin-15 enhances proliferation and chemokine secretion of human follicular dendritic cells. | |
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MedLine Citation:
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PMID: 20331472 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The germinal centre (GC) is a specialized microenvironment where high-affinity antibodies are produced through hypermutation and isotype switching. Follicular dendritic cells (FDCs) are the stromal cells of the GC. The timely expansion and establishment of an FDC network is essential for a protective GC reaction; however, only a few factors modulating FDC development have been recognized. In this study, we report that interleukin-15 (IL-15) enhances human primary FDC proliferation and regulates cytokine secretion. The FDCs express IL-15 receptor complexes for IL-15 signal transduction as well as for specific binding. Moreover, the secretion of chemokines CCL-2, CCL-5, CXCL-5 and CXCL-8 was reduced by blocking IL-15 signalling while the secretion of other cytokines, and the expression of CD14, CD44, CD54 (ICAM-1) and CD106 (VCAM-1) proteins remained unchanged. These results suggest that IL-15 plays a crucial role in the development of FDC networks during GC reaction, offering a new target for immune modulation. |
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Authors:
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Minchan Gil; Seo-Jeong Park; Yoo-Sam Chung; Chan-Sik Park |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-03-16 |
Journal Detail:
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Title: Immunology Volume: 130 ISSN: 1365-2567 ISO Abbreviation: Immunology Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-07-28 Completed Date: 2010-08-16 Revised Date: 2011-08-03 |
Medline Journal Info:
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Nlm Unique ID: 0374672 Medline TA: Immunology Country: England |
Other Details:
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Languages: eng Pagination: 536-44 Citation Subset: IM |
Affiliation:
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Department of Pathology, Asan Medical Centre, University of Ulsan College of Medicine, Seoul, Korea. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Cell Proliferation* Cells, Cultured Chemokines / immunology*, secretion* Dendritic Cells, Follicular / cytology, immunology*, metabolism, secretion* Humans Interleukin-15 / immunology*, metabolism Receptors, Interleukin-15 / genetics, immunology, metabolism Signal Transduction |
| Chemical | |
Reg. No./Substance:
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0/Chemokines; 0/Interleukin-15; 0/Receptors, Interleukin-15 |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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