| Interleukin 13 and inflammatory markers in human sepsis. | |
| | |
MedLine Citation:
|
PMID: 15164448 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: Interleukin (IL) 13 is an anti-inflammatory cytokine that reduces inflammatory cytokine production, and enhances monocyte survival and MHC class II and CD23 expression. The only report of IL-13 in human sepsis noted no increase in IL-13 concentration, in contrast to animal data. This study further examined the expression of IL-13 in relation to human sepsis. METHODS: In a prospective observational study of 31 patients (24 men) with sepsis or septic shock, high-sensitivity enzyme-linked immunoabsorbent assay (ELISA) was used to quantify levels of tumour necrosis factor (TNF) alpha on admission, and on days 1, 3, 5 and 7 thereafter. IL-13 and IL-2 were assayed by standard ELISA, and HLA-DR on CD14-positive monocytes was measured by flow cytometry. RESULTS: Twenty-three patients developed septic shock. Monocyte HLA-DR levels showed greater depression and a slower recovery in shocked than non-shocked patients. The serum IL-13 concentration was significantly higher in the shocked group from admission to day 3, but subsequently decreased to levels similar to those in the non-shocked group. IL-13 concentrations were higher in non-survivors. The TNF-alpha concentration was higher in those with septic shock than in those without. The TNF-alpha level correlated with IL-13 concentration (r(S) = 0.61, P = 0.002). The IL-13/TNF-alpha ratio was greater in patients with shock than those with sepsis only (P = 0.017). IL-2 was undetectable. CONCLUSION: In human sepsis and septic shock, IL-13 correlated with TNF-alpha expression, but its effect on HLA-DR class II molecules remains unclear. |
| | |
Authors:
|
N Collighan; P V Giannoudis; O Kourgeraki; S L Perry; P J Guillou; M C Bellamy |
Related Documents
:
|
9459618 - Cytokines in the sera of patients with pemphigus vulgaris: interleukin-6 and tumour nec... 20460338 - Nontraditional risk factors in carotid artery disease. 22781838 - Cortico-subcortical neuromodulation involved in the amelioration of prepulse inhibition... 8450178 - High dose l-carnitine improves immunologic and metabolic parameters in aids patients. 19143548 - Encapsulation of small ionic molecules within alpha-cyclodextrins. 115378 - Stimulation of cell-mediated resistance in mice to infection with listeria monocytogene... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: The British journal of surgery Volume: 91 ISSN: 0007-1323 ISO Abbreviation: Br J Surg Publication Date: 2004 Jun |
Date Detail:
|
Created Date: 2004-05-27 Completed Date: 2004-06-22 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0372553 Medline TA: Br J Surg Country: England |
Other Details:
|
Languages: eng Pagination: 762-8 Citation Subset: AIM; IM |
Copyright Information:
|
Copyright 2004 British Journal of Surgery Society Ltd. Published by John Wiley & Sons, Ltd. |
Affiliation:
|
Department of Anaesthesia, St James's University Hospital, Leeds LS9 7TF, UK. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Aged Biological Markers / blood Enzyme-Linked Immunosorbent Assay / methods Female HLA-DR Antigens / metabolism Humans Interleukin-13 / blood* Male Middle Aged Prospective Studies Sepsis / blood* Shock, Septic / blood* Tumor Necrosis Factor-alpha / metabolism |
| Chemical | |
Reg. No./Substance:
|
0/Biological Markers; 0/HLA-DR Antigens; 0/Interleukin-13; 0/Tumor Necrosis Factor-alpha |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Sacral nerve stimulation for faecal incontinence in the UK.
Next Document: Role of surgical portosystemic shunts in the era of interventional radiology and liver transplantati...