Document Detail

Interleukin 13 elicits a subset of the activities of its close relative interleukin 4.
MedLine Citation:
PMID:  7911047     Owner:  NLM     Status:  MEDLINE    
Interleukin 13 (IL-13) and interleukin 4 (IL-4) are two closely related proteins produced by activated T cells. IL-4 is a well characterized mediator of various aspects of the immune response, including anti-inflammatory effects on monocytes and macrophages, regulation of B cell function, T cell growth, and regulation of adhesion molecule expression on endothelial cells. IL-13, a more recently characterized cytokine, appears to exhibit IL-4-like activities on monocytes, macrophages and human B cells, but has no effect on T cells. While there is a close parallel between IL-4 activities on human and mouse cells, IL-13 activities in these two systems appear to differ substantially with a notable absence of effect on mouse B cells. This review briefly summarizes the current state of knowledge of the interrelated activities of IL-13 and IL-4, explores the basis of these effects at the receptor level and attempts to rationalize the existence of these close relatives via differences in their production by T cells.
G Zurawski; J E de Vries
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Stem cells (Dayton, Ohio)     Volume:  12     ISSN:  1066-5099     ISO Abbreviation:  Stem Cells     Publication Date:  1994 Mar 
Date Detail:
Created Date:  1994-07-05     Completed Date:  1994-07-05     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9304532     Medline TA:  Stem Cells     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  169-74     Citation Subset:  IM    
DNAX Research Institute of Molecular and Cellular Biology, Palo Alto, California 94303-1104.
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MeSH Terms
Interleukin-4 / immunology*
Interleukins / immunology*
Reg. No./Substance:
0/Interleukin-13; 0/Interleukins; 207137-56-2/Interleukin-4

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