| Interleukin 13 elicits a subset of the activities of its close relative interleukin 4. | |
MedLine Citation:
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PMID: 7911047 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Interleukin 13 (IL-13) and interleukin 4 (IL-4) are two closely related proteins produced by activated T cells. IL-4 is a well characterized mediator of various aspects of the immune response, including anti-inflammatory effects on monocytes and macrophages, regulation of B cell function, T cell growth, and regulation of adhesion molecule expression on endothelial cells. IL-13, a more recently characterized cytokine, appears to exhibit IL-4-like activities on monocytes, macrophages and human B cells, but has no effect on T cells. While there is a close parallel between IL-4 activities on human and mouse cells, IL-13 activities in these two systems appear to differ substantially with a notable absence of effect on mouse B cells. This review briefly summarizes the current state of knowledge of the interrelated activities of IL-13 and IL-4, explores the basis of these effects at the receptor level and attempts to rationalize the existence of these close relatives via differences in their production by T cells. |
Authors:
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G Zurawski; J E de Vries |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Stem cells (Dayton, Ohio) Volume: 12 ISSN: 1066-5099 ISO Abbreviation: Stem Cells Publication Date: 1994 Mar |
Date Detail:
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Created Date: 1994-07-05 Completed Date: 1994-07-05 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9304532 Medline TA: Stem Cells Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 169-74 Citation Subset: IM |
Affiliation:
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DNAX Research Institute of Molecular and Cellular Biology, Palo Alto, California 94303-1104. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Humans Interleukin-13 Interleukin-4 / immunology* Interleukins / immunology* |
| Chemical | |
Reg. No./Substance:
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0/Interleukin-13; 0/Interleukins; 207137-56-2/Interleukin-4 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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