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Interleukin-13 Deficiency Aggravates Healing and Remodeling in Male Mice After Experimental Myocardial Infarction.
MedLine Citation:
PMID:  24970469     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
BACKGROUND: -Activation of innate immunity, especially infiltration of monocytes, is critical for proper wound healing and scar formation after myocardial infarction (MI). Therefore, we tested the hypothesis that interleukin-13 (IL-13), which influences the differentiation of monocytes/ macrophages and has pro-fibrotic properties, modulates wound healing and remodelling after myocardial infarction.
METHODS AND RESULTS: -MI was induced by permanent ligation of the left coronary artery in both male and female WT/ IL-13(-/-) mice. Real-time-PCR demonstrated that expression of IL-13 was induced in left and right ventricular myocardium of WT mice within days in response to MI. 56-day survival was significantly impaired (65 % in WT vs 34% in IL-13(-/-)) in male but not female IL-13(-/-) (55 % in WT vs 54% in IL-13(-/-)) mice. Serial echocardiography showed significantly increased left ventricular dilation in male IL-13(-/-) compared to WT mice starting from day 1 after MI despite comparable infarct size. FACS analysis revealed less leukocyte infiltration in male IL-13(-/-) mice on day 3. Real-time-PCR analysis demonstrated reduced expression of marker genes of alternative activation in monocytes sorted from the infarct zone of male IL-13(-/-) in comparison to WT mice on day 3 after MI.
CONCLUSIONS: -Genetic deficiency of IL-13 worsens outcome after MI in male mice. Our data indicate that IL-13 regulates leukocyte recruitment and induces M2-like monocyte/ macrophage differentiation which modifies wound healing within the infarct zone.
Authors:
Ulrich Hofmann; Susanne Knorr; Benjamin Vogel; Johannes Weirather; Anna Frey; Georg Ertl; Stefan Frantz
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-6-26
Journal Detail:
Title:  Circulation. Heart failure     Volume:  -     ISSN:  1941-3297     ISO Abbreviation:  Circ Heart Fail     Publication Date:  2014 Jun 
Date Detail:
Created Date:  2014-6-27     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101479941     Medline TA:  Circ Heart Fail     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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