Document Detail

Interleukin-12p40 gene (IL-12B) polymorphism and Type 1 diabetes mellitus in Japanese: possible role in subjects without having high-risk HLA haplotypes.
MedLine Citation:
PMID:  16005098     Owner:  NLM     Status:  MEDLINE    
The present study was undertaken to clarify a role of interleukin-12p40 gene (IL-12B) polymorphism, located on chromosome 5q33-34 (IDDM 18), in Japanese subjects with Type 1 diabetes mellitus (T1DM) and autoimmune thyroid diseases (AITD). In 179 subjects with T1DM, 166 with AITD (128 with Graves' disease and 38 with Hashimoto's thyroiditis) and 115 healthy control subjects, the IL-12B 3'UTR A-C polymorphism was determined by PCR-RFLP method. In T1DM subjects, the genotype was also analyzed in relation to human leukocyte antigen (HLA)-DRB1-DQB1 haplotype status. There was a weak difference in the distribution of the genotype frequency between T1DM and control subjects, and the C allele frequency was higher in T1DM subjects (P<0.05). In 68 T1DM subjects without having high-risk HLA haplotypes to T1DM in this population, the genotype distribution and C allele frequency was significantly different from control subjects without high-risk HLA haplotypes (P<0.01), and from T1DM subjects with high-risk HLA haplotypes (n=111) (P<0.05). There was no difference in the genotype and allele frequencies between AITD and control subjects. In conclusion, the IL-12B 3'UTR A-C polymorphism did not seem to play a major role on genetic susceptibility to T1DM and AITD in Japanese, although the polymorphism conferred susceptibility in T1DM subjects without having high-risk HLA haplotypes. The IL-12B 3'UTR A-C polymorphism would be considered as a supplementary risk factor to T1DM in conjunction with HLA haplotypes.
Jian Mei Yang; Shoichiro Nagasaka; Toshimitsu Yatagai; Tomoatsu Nakamura; Ikuyo Kusaka; San-e Ishikawa; Toshikazu Saito; Shun Ishibashi
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Publication Detail:
Type:  Journal Article     Date:  2005-07-06
Journal Detail:
Title:  Diabetes research and clinical practice     Volume:  71     ISSN:  0168-8227     ISO Abbreviation:  Diabetes Res. Clin. Pract.     Publication Date:  2006 Feb 
Date Detail:
Created Date:  2006-01-23     Completed Date:  2006-06-13     Revised Date:  2010-10-15    
Medline Journal Info:
Nlm Unique ID:  8508335     Medline TA:  Diabetes Res Clin Pract     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  164-9     Citation Subset:  IM    
Division of Endocrinology and Metabolism, Department of Medicine, Jichi Medical School, Yakushiji 3311-1, Minamikawachi, Tochigi 329-0498, Japan.
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MeSH Terms
Age of Onset
Chromosome Mapping
Chromosomes, Human, Pair 3*
Diabetes Mellitus, Type 1 / genetics*,  immunology*
HLA Antigens*
HLA-DQ Antigens / genetics
HLA-DR Antigens / genetics
Interleukin-12 / genetics*
Interleukin-12 Subunit p40
Polymorphism, Genetic*
Polymorphism, Single Nucleotide*
Reg. No./Substance:
0/HLA Antigens; 0/HLA-DQ Antigens; 0/HLA-DQB1 antigen; 0/HLA-DR Antigens; 0/IL12B protein, human; 0/Interleukin-12 Subunit p40; 128338-86-3/HLA-DRB1 antigen; 187348-17-0/Interleukin-12

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