Document Detail

Interleukin-12 but not interleukin-18 is associated with severe endometriosis.
MedLine Citation:
PMID:  18295214     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To evaluate interleukin (IL)-12 and IL-18 levels in the serum and peritoneal fluid of women with and without endometriosis. DESIGN: Cross-sectional survey. SETTING: University hospital. PATIENTS: Interleukin-12 and IL-18 levels were compared in 105 patients submitted to laparoscopy because of symptoms suggestive of endometriosis (pain and/or infertility). The disease was confirmed in 72 patients (study group), while in 33 patients findings were not compatible with endometriosis (control group). INTEVENTION(S): Blood sample and peritoneal fluid were obtained from patients during videolaparoscopy. MAIN OUTCOME MEASURE(S): The levels of IL-12 and IL-18 in peripheral blood and peritoneal fluid were determined and compared with the stage and site of the disease and histologic classification. RESULT(S): IL-12 levels measured in peritoneal fluid were higher in patients with endometriosis compared with the control group. A significant increase in IL-12 levels was found when the more advanced stages of the disease were compared with the initial stages. No statistically significant differences were found in IL-18 levels, either in serum or in peritoneal fluid samples. CONCLUSION(S): Patients with severe endometriosis have higher IL-12 levels irrespective of IL-18 levels, suggesting that in this disease an alternative pathway is involved in induction of the Th1 immune response.
Flávia Fairbanks; Mauricio S Abrão; Sergio Podgaec; João Antonio Dias; Ricardo M de Oliveira; Luiz Vicente Rizzo
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-03-04
Journal Detail:
Title:  Fertility and sterility     Volume:  91     ISSN:  1556-5653     ISO Abbreviation:  Fertil. Steril.     Publication Date:  2009 Feb 
Date Detail:
Created Date:  2009-02-09     Completed Date:  2009-02-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372772     Medline TA:  Fertil Steril     Country:  United States    
Other Details:
Languages:  eng     Pagination:  320-4     Citation Subset:  IM    
Endometriosis Unit, Gynecological Clinic, São Paulo University School of Medicine, São Paulo, SP, Brazil.
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MeSH Terms
Ascitic Fluid / immunology*
Biological Markers / analysis
Case-Control Studies
Cross-Sectional Studies
Endometriosis / immunology*,  pathology
Interleukin-12 / analysis*,  blood
Interleukin-18 / analysis*,  blood
Pilot Projects
Severity of Illness Index
Video-Assisted Surgery
Young Adult
Reg. No./Substance:
0/Biological Markers; 0/Interleukin-18; 187348-17-0/Interleukin-12

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