| Interleukin-11 regulates the hepatic expression of the same plasma protein genes as interleukin-6. | |
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MedLine Citation:
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PMID: 1718962 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Treatment of rat hepatoma H-35 cells with purified human recombinant interleukin-11 (IL-11) resulted in the stimulated production of several major acute phase plasma proteins. The qualitative and quantitative changes were comparable to those mediated by IL-6 or leukemia inhibitor factor (LIF). Like IL-6, IL-11 acted synergistically with IL-1 on type 1 acute phase proteins. The combination of IL-11 and dexamethasone yielded a magnitude of stimulation which was more similar to the combination of LIF and dexamethasone than IL-6 and dexamethasone. IL-11 elicited in treatment of primary cultures of rat hepatocytes a qualitative change of plasma protein production which was similar to that in H-35 cells. Comparison of rat and human hepatoma cells indicated that the IL-11 response did not correlate with that of IL-6 or LIF, suggesting that the action of IL-11 was mediated by an IL-11-specific receptor system. However, the intracellular transduction of the IL-11, IL-6, and LIF signals to the acute phase protein genes seems to rely, in part, on common elements as judged from their stimulatory effects on the transfected expression vector containing the IL-6 response element of the rat beta-fibrinogen gene. The finding that IL-11 shares liver-regulating properties with IL-6 and LIF suggests that IL-11 has the potential of contributing to the control of systemic homeostasis and hepatic acute phase response. |
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Authors:
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H Baumann; P Schendel |
Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: The Journal of biological chemistry Volume: 266 ISSN: 0021-9258 ISO Abbreviation: J. Biol. Chem. Publication Date: 1991 Oct |
Date Detail:
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Created Date: 1991-12-02 Completed Date: 1991-12-02 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 2985121R Medline TA: J Biol Chem Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 20424-7 Citation Subset: IM |
Affiliation:
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Department of Molecular and Cellular Biology, Roswell Park Cancer Institute, Buffalo, New York 14263. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acute-Phase Proteins
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genetics* Animals Chloramphenicol O-Acetyltransferase / genetics Gene Expression Regulation* Humans Interleukin-11 Interleukin-6 / pharmacology* Interleukins / pharmacology* Liver / cytology, drug effects* Male Neutralization Tests Rats Rats, Inbred F344 Recombinant Proteins / pharmacology |
| Grant Support | |
ID/Acronym/Agency:
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CA26122/CA/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Acute-Phase Proteins; 0/Interleukin-11; 0/Interleukin-6; 0/Interleukins; 0/Recombinant Proteins; EC 2.3.1.28/Chloramphenicol O-Acetyltransferase |
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