| Interleukin-10 signaling in regulatory T cells is required for suppression of Th17 cell-mediated inflammation. | |
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MedLine Citation:
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PMID: 21511185 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Effector CD4+ T cell subsets, whose differentiation is facilitated by distinct cytokine cues, amplify the corresponding type of inflammatory response. Regulatory T (Treg) cells integrate environmental cues to suppress particular types of inflammation. In this regard, STAT3, a transcription factor essential for T helper 17 (Th17) cell differentiation, is necessary for Treg cell-mediated control of Th17 cell responses. Here, we showed that anti-inflammatory interleukin-10 (IL-10), and not proinflammatory IL-6 and IL-23 cytokine signaling, endowed Treg cells with the ability to suppress pathogenic Th17 cell responses. Ablation of the IL-10 receptor in Treg cells resulted in selective dysregulation of Th17 cell responses and colitis similar to that observed in mice harboring STAT3-deficient Treg cells. Thus, Treg cells limit Th17 cell inflammation by serving as principal amplifiers of negative regulatory circuits operating in immune effector cells. |
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Authors:
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Ashutosh Chaudhry; Robert M Samstein; Piper Treuting; Yuqiong Liang; Marina C Pils; Jan-Michael Heinrich; Robert S Jack; F Thomas Wunderlich; Jens C Brüning; Werner Müller; Alexander Y Rudensky |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Immunity Volume: 34 ISSN: 1097-4180 ISO Abbreviation: Immunity Publication Date: 2011 Apr |
Date Detail:
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Created Date: 2011-04-22 Completed Date: 2011-06-17 Revised Date: 2013-03-26 |
Medline Journal Info:
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Nlm Unique ID: 9432918 Medline TA: Immunity Country: United States |
Other Details:
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Languages: eng Pagination: 566-78 Citation Subset: IM |
Copyright Information:
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Copyright © 2011 Elsevier Inc. All rights reserved. |
Affiliation:
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Howard Hughes Medical Institute and Immunology Program, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Lineage Colitis / immunology*, pathology Interleukin-10 / immunology*, metabolism Mice Mice, Knockout Phosphorylation Receptors, Interleukin-10 / deficiency, immunology STAT3 Transcription Factor / immunology, metabolism Signal Transduction* T-Lymphocytes, Regulatory / cytology, immunology* Th17 Cells / immunology* |
| Grant Support | |
ID/Acronym/Agency:
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F30 DK091968/DK/NIDDK NIH HHS; GM07739/GM/NIGMS NIH HHS; R37 AI034206-19/AI/NIAID NIH HHS; //Howard Hughes Medical Institute |
| Chemical | |
Reg. No./Substance:
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0/IL10 protein, mouse; 0/Receptors, Interleukin-10; 0/STAT3 Transcription Factor; 0/Stat3 protein, mouse; 130068-27-8/Interleukin-10 |
| Comments/Corrections | |
Comment In:
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Immunity. 2011 Apr 22;34(4):460-2
[PMID:
21511180
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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