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Interleukin 10 and residual kidney function are associated with risk of vascular calcification in patients undergoing peritoneal dialysis.
MedLine Citation:
PMID:  21543018     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Aims: Vascular calcification is a common complication among dialysis patients and its pathogenesis involves a variety of factors. The roles of pro-inflammatory cytokines and residual kidney function (RKF) in peritoneal dialysis (PD) patients with vascular calcification have not been investigated. Materials and methods: 157 stable PD patients were enrolled. All patients had plain X-ray film examination including chest (posterior-anterior view, CXR) and pelvis. Vascular calcification was interpreted as calcified deposit over aortic arch and linear calcification of pelvic arteries. Relevant biochemical data, pro-inflammatory markers, and PD-related factors were measured and collected. Results: Vascular calcification prevalence in CXRs was higher than that in pelvis films (38.2% vs. 22.3%, p < 0.05). Patients with vascular calcification in CXR had higher incidence of calcification in pelvis films (p < 0.05). Only a minor portion (14.6%) had two calcification sites. Regression analysis revealed that age, PD duration, body mass index, and RKF were independent factors associated with vascular calcification in CXR. Age, diabetes, IL-10 and RKF were factors associated in pelvis films. Factors independently related to vascular calcification in both films were age, duration, diabetes, IL-10, and RKF. Conclusions: Besides traditional risk factors, IL-10 and RKF were important factors associated with vascular calcification in PD patients.
Authors:
C-T Lee; Y-C Tsai; C-Y Su; H-Y Ng; C-Y Hsu; S-F Ko; T-C Chen; C-C Kuo; C-C Yang; T T-Y Chiou; W-C Lee; Y-K Yang; K-K Lam
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical nephrology     Volume:  75     ISSN:  0301-0430     ISO Abbreviation:  Clin. Nephrol.     Publication Date:  2011 May 
Date Detail:
Created Date:  2011-05-05     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0364441     Medline TA:  Clin Nephrol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  397-402     Citation Subset:  IM    
Affiliation:
1Division of Nephrology, Department of Internal Medicine, Chang-Gung Memorial Hospital Kaohsiung Medical Center, Chang-Gung University College of Medicine, 2Department of Neurology, Kaohsiung Medical University, and 3Department of Radiology, Chang-Gung Memorial Hospital Kaohsiung Medical Center, Chang-Gung University College of Medicine, Kaohsiung, Taiwan.
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