| Interleukin-10 promoter polymorphisms in rheumatoid arthritis and Felty's syndrome. | |
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MedLine Citation:
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PMID: 9783765 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To examine whether promoter polymorphisms associated with variation in interleukin-10 (IL-10) production are relevant to the development of rheumatoid arthritis (RA) or Felty's syndrome (FS). METHODS: DNA was obtained from 44 FS patients, 117 RA patients and 295 controls. The promoter region between -533 and - 1120 was amplified by polymerase chain reaction, and polymorphisms detected by restriction enzyme digest or sequence-specific oligonucleotide probing. RESULTS: We found no significant difference in allele or haplotype frequencies between the groups. CONCLUSION: There is no association between FS or RA and these recently identified IL-10 promoter polymorphisms. Other genetic or environmental factors could explain the alterations in IL-10 levels seen in these conditions. |
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Authors:
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G Coakley; C C Mok; A H Hajeer; W E Ollier; D Turner; P J Sinnott; I V Hutchinson; G S Panayi; J S Lanchbury |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: British journal of rheumatology Volume: 37 ISSN: 0263-7103 ISO Abbreviation: Br. J. Rheumatol. Publication Date: 1998 Sep |
Date Detail:
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Created Date: 1998-10-27 Completed Date: 1998-10-27 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 8302415 Medline TA: Br J Rheumatol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 988-91 Citation Subset: AIM; IM |
Affiliation:
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Department of Rheumatology, Guy's, King's and St Thomas' School of Medicine, Guy's Hospital, London. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Arthritis, Rheumatoid
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genetics*,
immunology Case-Control Studies Felty's Syndrome / genetics*, immunology Humans Interleukin-10 / genetics* Polymorphism, Genetic Promoter Regions, Genetic / genetics* |
| Chemical | |
Reg. No./Substance:
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130068-27-8/Interleukin-10 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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