Document Detail


Interleukin-10 promoter polymorphisms in rheumatoid arthritis and Felty's syndrome.
MedLine Citation:
PMID:  9783765     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To examine whether promoter polymorphisms associated with variation in interleukin-10 (IL-10) production are relevant to the development of rheumatoid arthritis (RA) or Felty's syndrome (FS). METHODS: DNA was obtained from 44 FS patients, 117 RA patients and 295 controls. The promoter region between -533 and - 1120 was amplified by polymerase chain reaction, and polymorphisms detected by restriction enzyme digest or sequence-specific oligonucleotide probing. RESULTS: We found no significant difference in allele or haplotype frequencies between the groups. CONCLUSION: There is no association between FS or RA and these recently identified IL-10 promoter polymorphisms. Other genetic or environmental factors could explain the alterations in IL-10 levels seen in these conditions.
Authors:
G Coakley; C C Mok; A H Hajeer; W E Ollier; D Turner; P J Sinnott; I V Hutchinson; G S Panayi; J S Lanchbury
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  British journal of rheumatology     Volume:  37     ISSN:  0263-7103     ISO Abbreviation:  Br. J. Rheumatol.     Publication Date:  1998 Sep 
Date Detail:
Created Date:  1998-10-27     Completed Date:  1998-10-27     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8302415     Medline TA:  Br J Rheumatol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  988-91     Citation Subset:  AIM; IM    
Affiliation:
Department of Rheumatology, Guy's, King's and St Thomas' School of Medicine, Guy's Hospital, London.
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MeSH Terms
Descriptor/Qualifier:
Arthritis, Rheumatoid / genetics*,  immunology
Case-Control Studies
Felty's Syndrome / genetics*,  immunology
Humans
Interleukin-10 / genetics*
Polymorphism, Genetic
Promoter Regions, Genetic / genetics*
Chemical
Reg. No./Substance:
130068-27-8/Interleukin-10

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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