| Interleukin 10 genotype as a risk factor for sudden infant death syndrome: determination of IL-10 genotype from wax-embedded postmortem samples. | |
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MedLine Citation:
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PMID: 15325405 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In a previous study an association was shown between SIDS and an interleukin-10 (IL-10) genotype. That study was carried out on frozen, unfixed tissue samples, but these are difficult to obtain. Fixed samples used for pathological examination are available. The purpose of this study was to extend the previous work by establishing methods to extract and genotype DNA from fixed, wax-embedded tissues specimens and to use the results to seek confirmation of the association between IL-10 genotype and SIDS in a larger collection of SIDS babies. Using an amplification refractory mutation system-polymerase chain reaction method, a total of 38 infants were genotyped for IL-10 alleles and compared with controls. There was a significant association between the IL-10 -592*A allele and SIDS, consistent with the earlier findings. This study lends support to the hypothesis that IL-10 genotype is related to the susceptibility of babies to SIDS. |
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Authors:
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May Korachi; Vera Pravica; Anthony J Barson; Ian V Hutchinson; David B Drucker |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: FEMS immunology and medical microbiology Volume: 42 ISSN: 0928-8244 ISO Abbreviation: FEMS Immunol. Med. Microbiol. Publication Date: 2004 Sep |
Date Detail:
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Created Date: 2004-08-24 Completed Date: 2004-10-28 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9315554 Medline TA: FEMS Immunol Med Microbiol Country: Netherlands |
Other Details:
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Languages: eng Pagination: 125-9 Citation Subset: IM |
Affiliation:
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Oral Microbiology Laboratory, University Dental Hospital of Manchester, Higher Cambridge Street, Manchester M15 6FH, UK. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Autopsy Genetic Predisposition to Disease Genotype Humans Infant Interleukin-10 / genetics* Polymerase Chain Reaction Risk Factors Sudden Infant Death / genetics* Tissue Embedding / methods Waxes |
| Chemical | |
Reg. No./Substance:
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0/Waxes; 130068-27-8/Interleukin-10 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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