Document Detail


Interleukin 10 genotype as a risk factor for sudden infant death syndrome: determination of IL-10 genotype from wax-embedded postmortem samples.
MedLine Citation:
PMID:  15325405     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In a previous study an association was shown between SIDS and an interleukin-10 (IL-10) genotype. That study was carried out on frozen, unfixed tissue samples, but these are difficult to obtain. Fixed samples used for pathological examination are available. The purpose of this study was to extend the previous work by establishing methods to extract and genotype DNA from fixed, wax-embedded tissues specimens and to use the results to seek confirmation of the association between IL-10 genotype and SIDS in a larger collection of SIDS babies. Using an amplification refractory mutation system-polymerase chain reaction method, a total of 38 infants were genotyped for IL-10 alleles and compared with controls. There was a significant association between the IL-10 -592*A allele and SIDS, consistent with the earlier findings. This study lends support to the hypothesis that IL-10 genotype is related to the susceptibility of babies to SIDS.
Authors:
May Korachi; Vera Pravica; Anthony J Barson; Ian V Hutchinson; David B Drucker
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  FEMS immunology and medical microbiology     Volume:  42     ISSN:  0928-8244     ISO Abbreviation:  FEMS Immunol. Med. Microbiol.     Publication Date:  2004 Sep 
Date Detail:
Created Date:  2004-08-24     Completed Date:  2004-10-28     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9315554     Medline TA:  FEMS Immunol Med Microbiol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  125-9     Citation Subset:  IM    
Affiliation:
Oral Microbiology Laboratory, University Dental Hospital of Manchester, Higher Cambridge Street, Manchester M15 6FH, UK.
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MeSH Terms
Descriptor/Qualifier:
Autopsy
Genetic Predisposition to Disease
Genotype
Humans
Infant
Interleukin-10 / genetics*
Polymerase Chain Reaction
Risk Factors
Sudden Infant Death / genetics*
Tissue Embedding / methods
Waxes
Chemical
Reg. No./Substance:
0/Waxes; 130068-27-8/Interleukin-10

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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