| An Interleukin-10 Gene Promoter Polymorphism (-592A/C) Associated with Type 2 Diabetes: A North Indian Study. | |
| | |
MedLine Citation:
|
PMID: 22298356 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
In this first report on the association of an IL-10 promoter polymorphism with type 2 diabetes mellitus in a North Indian population, the -592A/C SNP (rs1800872) was genotyped by PCR-RFLP and the IL-10 level measured using ELISA. Although no significant difference was observed in the genotypic frequencies (P = 0.657), diabetes patients carried a significantly higher number of A alleles at the -592 position, 25.6% (P < 0.001, odds ratio 0.887, 95% CI 0.670-1.184). Significant correlations were detected in postprandial glucose levels of CC-genotype patients and controls (P = 0.025), age and waist-hip ratio of CA patients and controls (P ≤ 0.001), and fasting glucose (P = 0.045) and low-density lipoprotein (P = 0.049) in all patients and controls. The serum IL-10 level was significantly higher in patients than in controls (P = 0.033). The polymorphism was significantly associated with disease incidence and its biochemical manifestations. |
| | |
Authors:
|
Madhukar Saxena; C G Agrawal; Hemant Kumar Bid; Monisha Banerjee |
Related Documents
:
|
7045486 - Carcinomas of the cervix and corpus uteri in humans: stage-dependent blood levels of su... 20182396 - Epidemiological study of pancreatic diabetes in japan in 2005: a nationwide study. 6601596 - Evaluation of exocrine pancreatic function by oral administration of n-benzoyl-l-tyrosy... 7249936 - Hyperglycemia associated with propranolol and chlorpropamide coadministration. 19159946 - Effect of a 20-day ski trek on fuel selection during prolonged exercise at low workload... 15692106 - Hypoadiponectinemia is associated with ischemic cerebrovascular disease. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2012-2-2 |
Journal Detail:
|
Title: Biochemical genetics Volume: - ISSN: 1573-4927 ISO Abbreviation: - Publication Date: 2012 Feb |
Date Detail:
|
Created Date: 2012-2-2 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0126611 Medline TA: Biochem Genet Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
Molecular and Human Genetics Laboratory, Department of Zoology, University of Lucknow, Lucknow, 226007, India. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Determination of Genetic Diversity of Vitis vinifera cv. Kabarcik Populations from the Coruh Valley ...
Next Document: Genotyping an ALAD Polymorphism with Real-Time PCR in Two Populations from the Iberian Peninsula.