Document Detail


Interleukin 1.
MedLine Citation:
PMID:  2469399     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The last decade has witnessed a remarkable expansion in the understanding of the skin as an immunologic organ. A prime example of this is the discovery that keratinocytes can synthesize and secrete immunoregulatory and proinflammatory glycoproteins termed cytokines. Initial studies focused on interleukin 1-like molecules produced by keratinocytes, initially termed epidermal cell-derived thymocyte activating factor (ETAF). It is now clear that the functional activities described by the term ETAF are composed mainly of interleukin 1 alpha and interleukin 1 beta, although other epidermal cytokines may contribute to the biologic activity. The biologic properties of interleukin 1 are the basis of this review.
Authors:
D N Sauder
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Archives of dermatology     Volume:  125     ISSN:  0003-987X     ISO Abbreviation:  Arch Dermatol     Publication Date:  1989 May 
Date Detail:
Created Date:  1989-06-01     Completed Date:  1989-06-01     Revised Date:  2008-03-17    
Medline Journal Info:
Nlm Unique ID:  0372433     Medline TA:  Arch Dermatol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  679-82     Citation Subset:  AIM; IM    
Affiliation:
Department of Medicine, McMaster University, Hamilton, Ontario, Canada.
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MeSH Terms
Descriptor/Qualifier:
Animals
Epidermis / metabolism
Humans
Inflammation / metabolism
Interleukin-1* / metabolism,  physiology
Keratins
Lymphocytes / immunology
Molecular Structure
Tumor Necrosis Factor-alpha / physiology
Chemical
Reg. No./Substance:
0/Interleukin-1; 0/Tumor Necrosis Factor-alpha; 68238-35-7/Keratins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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