Document Detail


Interleukin 1 receptor antagonist reduces lethality and intestinal toxicity of 5-Fluorouracil in a mouse mucositis model.
MedLine Citation:
PMID:  21723691     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Chemotherapy induced intestinal mucositis is still an unmet medical problem. 5-fluorouracil (5-Fu), a chemotherapy drug, was used to create the animal model of mucositis. Global gene expression array was applied to identify genetic signals involved in the pathogenesis of mucositis. Interleukin 1 receptor antagonist (IL-1Ra) was one of the candidates with the characteristic gene expression profile. Its temporal expression pattern correlated to the damage and regeneration phase of the small intestine after a single injection of 5-Fu to mice. Administration of recombinant IL-1Ra to the mouse model of intestinal mucositis induced by 5-Fu demonstrated its therapeutic effects to the symptoms and pathology of the disease. The IL-1Ra treatment reduced the acute lethality, accelerated their body weight recovery, and eliminated severe diarrhea. The symptomatic benefits were supported by the pathological benefits, in which the mice treated with IL-1Ra has less damage and faster recovery of the structure integrity of their small intestine than that of the mice treated with vehicle control. To deliver the therapeutics to the unmet medical condition, further mechanism and translational studies of IL-1Ra in the settings of chemotherapy induced intestinal mucositis are warranted.
Authors:
Zhenqian Wu; Xiaodong Han; Shenyin Qin; Qi Zheng; Zhigang Wang; Di Xiang; Jing Zhang; Huili Lu; Mingyuan Wu; Shunying Zhu; Yan Yu; Yu Wang; Wei Han
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-6-15
Journal Detail:
Title:  Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie     Volume:  -     ISSN:  1950-6007     ISO Abbreviation:  -     Publication Date:  2011 Jun 
Date Detail:
Created Date:  2011-7-4     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8213295     Medline TA:  Biomed Pharmacother     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011. Published by Elsevier SAS.
Affiliation:
Department of General Surgery, The Affiliated Sixth Hospital of Medical School, Shanghai Jiao Tong University, Shanghai 200233, PR China.
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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