| Interleukin 1 receptor antagonist and E-selectin concentrations: a comparison in patients with severe acute pancreatitis and severe sepsis. | |
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MedLine Citation:
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PMID: 10382785 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: This prospective clinical study was designed to compare interleukin 1 receptor antagonist (IL-1ra) and E-selectin concentrations in patients with severe acute pancreatitis to those with severe sepsis. MATERIALS AND METHODS: Nine consecutive patients with severe acute pancreatitis and 11 consecutive patients with severe sepsis admitted to a medical/surgical intensive care unit were included in the study. Plasma concentrations of IL-1ra and E-selectin were serially measured daily for 7 days or throughout their stay in the intensive care unit if shorter. RESULTS: The concentrations of IL-1ra were significantly higher on admission in patients with severe sepsis compared with the patients with severe pancreatitis (median levels 10,500 and 2,600 pg/mL, respectively, P = .007). When the data from the first 3 days were analyzed using analysis of variance (ANOVA), the levels of IL-1ra and E-selectin were similar in both groups. The concentrations of IL-1ra and E-selectin correlated to the development of multiorgan dysfunction as assessed by sequential organ failure assessment (SOFA) score (P = .032 and .043, respectively). CONCLUSION: This study shows that IL-1ra and E-selectin are released in acute severe pancreatitis, and the levels seem to be comparable to those in patients with severe sepsis. Concentrations of IL-1ra and E-selectin correlate to the development of multiorgan failure as indicated by high SOFA scores during the first week of disease. |
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Authors:
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M Hynninen; M Valtonen; H Markkanen; M Vaara; P Kuusela; I Jousela; A Piilonen; O Takkunen |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of critical care Volume: 14 ISSN: 0883-9441 ISO Abbreviation: J Crit Care Publication Date: 1999 Jun |
Date Detail:
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Created Date: 1999-07-29 Completed Date: 1999-07-29 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8610642 Medline TA: J Crit Care Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 63-8 Citation Subset: IM |
Affiliation:
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Department of Surgery, Helsinki University Hospital, Finland. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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APACHE Acute Disease Adult Aged Analysis of Variance E-Selectin / blood* Female Humans Interleukin 1 Receptor Antagonist Protein Male Middle Aged Multiple Organ Failure / etiology Pancreatitis / blood*, complications, immunology*, mortality Predictive Value of Tests Prognosis Prospective Studies Sepsis / blood*, complications, immunology*, mortality Severity of Illness Index Sialoglycoproteins / blood* Time Factors |
| Chemical | |
Reg. No./Substance:
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0/E-Selectin; 0/IL1RN protein, human; 0/Interleukin 1 Receptor Antagonist Protein; 0/Sialoglycoproteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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